Thrombotic thrombocytopenic purpura in a new onset lupus patient?

We are presenting a case of TTP with undetectable levels of ADAMTS 13 in a 39-year-old woman. Diagnosis of systemic lupus was evoked in the setting of thrombotic microangiopathy. The patient presented normal renal function but important neurological impairment. Treatment with daily plasmapheresis as...

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Bibliographic Details
Published in:Immunologic research 2017-04, Vol.65 (2), p.454-458
Main Authors: González, Nery Sablón, Lorenzo, Noel, Parodis, Yanet, Ortiz, Maria Belen Alonso, Kechida, Melek, Perez, Jose Carlos Rodriguez
Format: Article
Language:English
Subjects:
2017
Adult
Allergology
Anemia, Hemolytic - diagnosis
Autoantibodies - blood
Autoimmune diseases
Biomedical and Life Sciences
Biomedicine
Blood Platelets - immunology
Codeine - therapeutic use
Cyclophosphamide - therapeutic use
Female
Humans
Hydroxychloroquine - therapeutic use
Immunology
Internal Medicine
Lupus
Lupus Erythematosus, Systemic
Medicine/Public Health
Monoclonal antibodies
Novel Aspects in Lupus
Plasmapheresis
Purpura, Thrombotic Thrombocytopenic - diagnosis
Purpura, Thrombotic Thrombocytopenic - immunology
Remission Induction
Rituximab - therapeutic use
Sjogren's Syndrome - drug therapy
Systemic lupus erythematosus
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Description
Summary:We are presenting a case of TTP with undetectable levels of ADAMTS 13 in a 39-year-old woman. Diagnosis of systemic lupus was evoked in the setting of thrombotic microangiopathy. The patient presented normal renal function but important neurological impairment. Treatment with daily plasmapheresis as well as Rituximab, cyclophosphamide as steroids was required to achieve clinical improvement.
ISSN:0257-277X
1559-0755
DOI:10.1007/s12026-017-8898-y