Design, formulation and sensory evaluation of a polyphenol-rich food placebo: an example of aronia juice for food intervention studies

Products suitable for use as controls in food interventions designed to demonstrate the role of minor components are largely lacking. In the present study, we aimed to develop a formulation to be used as a placebo in a clinical trial designed to assess the effects of aronia juice polyphenols on plat...

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Bibliographic Details
Published in:International journal of food sciences and nutrition 2017-09, Vol.68 (6), p.742-749
Main Authors: Kardum, Nevena, Konic Ristic, Aleksandra, Zec, Manja, Kojadinovic, Milica, Petrovic-Oggiano, Gordana, Zekovic, Milica, Kroon, Paul A., Glibetić, Maria
Format: Article
Language:English
Subjects:
Adult
Alanine Transaminase - blood
anthocyanins
Anthropometry
Aronia melanocarpa
Aspartate Aminotransferases - blood
bioactives
Cholesterol - blood
Clinical trials
Creatinine - blood
Diet
Female
Flavors
Food
Food production
Food science
Formulations
Fruit and Vegetable Juices - analysis
functional food
Humans
Intervention
Juices
Male
Middle Aged
Nutrients
Olfaction
Photinia - chemistry
Pilot Projects
Placebos - administration & dosage
Placebos - chemistry
Plant Extracts - pharmacology
Platelet Activation - drug effects
Platelet Aggregation - drug effects
platelet function
Platelets
Polyphenols
Polyphenols - administration & dosage
Polyphenols - chemistry
Sensory evaluation
Smell
Taste
Triglycerides - blood
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Summary:Products suitable for use as controls in food interventions designed to demonstrate the role of minor components are largely lacking. In the present study, we aimed to develop a formulation to be used as a placebo in a clinical trial designed to assess the effects of aronia juice polyphenols on platelet function. Three formulations with the same nutrient composition as aronia juice were prepared by mixing various nutrients, artificial colours and flavours with water. The similarity of formulations to aronia juice in terms of taste, colour, smell and texture was assessed by six food panellists. The final placebo was tested for its impact on platelet function, biochemical and anthropometric parameters in a 4-week long study. No significant changes in platelet function, or in several cardiovascular and safety markers were recorded. Formulation suitable for use as a placebo for dietary intervention studies using aronia juice has been developed and demonstrated to be well tolerated in humans.
ISSN:0963-7486
1465-3478
DOI:10.1080/09637486.2017.1283682