Endoneurial-CD34 positive cells define an intermediate layer in human digital Pacinian corpuscles

The endoneurial and/or perineurial origin of the outer core; i.e. the concentric and continuous lamellae located outside the complex formed by the axon and the Schwann-related cells, in human Pacinian corpuscles is still debated. Here we used immunohistochemistry coupled with a battery of antibodies...

Full description

Saved in:
Bibliographic Details
Published in:Annals of anatomy 2017-05, Vol.211, p.55-60
Main Authors: García-Piqueras, J., García-Suárez, O., Rodríguez-González, M.C., Cobo, J.L., Cabo, R., Vega, J.A., Feito, J.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Antigens, CD34 - metabolism
Cadaver
CD34 antigen
Endoneurium
Female
Fingers - anatomy & histology
Fingers - innervation
Glucose Transporter Type 1 - metabolism
Human
Humans
Immunohistochemistry
Male
Middle Aged
Mucin-1 - metabolism
Pacinian corpuscles
Pacinian Corpuscles - cytology
Pacinian Corpuscles - metabolism
Peripheral Nerves - metabolism
Peripheral Nerves - ultrastructure
Tissue Distribution
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The endoneurial and/or perineurial origin of the outer core; i.e. the concentric and continuous lamellae located outside the complex formed by the axon and the Schwann-related cells, in human Pacinian corpuscles is still debated. Here we used immunohistochemistry coupled with a battery of antibodies to investigate the expression of perineurial (Glucose transporter 1 and epithelial membrane antigen) or endoneurial (CD34 antigen) markers in human digital Pacinian corpuscles. CD34 immunoreactivity was restricted to one layer immediately outside the inner core, whereas the proper outer core displayed antigens typical of the perineurial cells. These results demonstrate an intermediate endoneurial layer that divides the Pacinian corpuscles into two distinct compartments: the avascular inner neural compartment (formed by the axon and the Schwann-related cells that form the inner core), and the outer non-neural compartment (formed by the outer core). The functional relevance of these findings, if any, remains to be clarified.
ISSN:0940-9602
1618-0402
DOI:10.1016/j.aanat.2017.01.006