Daily Ingestion of Aloe Vera Gel Powder Containing Aloe Sterols Prevents Skin Photoaging in OVX Hairless Mice

Estrogen deficiencies associated with menopause accelerate spontaneous skin aging and stimulate the ultraviolet (UV) irradiation‐induced photoaging of skin. However, food compositions with the potential to ameliorate the UV irradiation‐induced acceleration of skin aging with menopause have not yet b...

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Bibliographic Details
Published in:Journal of food science 2016-11, Vol.81 (11), p.H2849-H2857
Main Authors: Yao, Ruiqing, Tanaka, Miyuki, Misawa, Eriko, Saito, Marie, Nabeshima, Kazumi, Yamauchi, Koji, Abe, Fumiaki, Yamamoto, Yuki, Furukawa, Fukumi
Format: Article
Language:English
Subjects:
Acceleration
Aging
Aging (artificial)
Aloe
Aloe vera
Aloe vera gel
Damage prevention
Dietary supplements
EGF
estrogen deficiency
Irradiation
Mice
MMPs
photoaging
Radiation damage
Skin
Sterols
Ultraviolet
Ultraviolet radiation
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Summary:Estrogen deficiencies associated with menopause accelerate spontaneous skin aging and stimulate the ultraviolet (UV) irradiation‐induced photoaging of skin. However, food compositions with the potential to ameliorate the UV irradiation‐induced acceleration of skin aging with menopause have not yet been investigated in detail. In the present study, we examined the ability of plant sterols derived from Aloe vera gel to prevent the UV irradiation‐induced acceleration of skin aging in ovariectomized mice. Skin transepidermal water loss (TEWL) was significantly higher in the ovariectomy group than in the sham operation group following UVB irradiation, whereas skin elasticity was significantly lower. Ultraviolet B (UVB) irradiation induced greater reductions in skin hyaluronic acid levels and more severe collagen fiber damage in the derims in the ovariectomy group than in the sham group. The intake of AVGP significantly ameliorated this acceleration in skin aging by reducing the expression of matrix metalloproteinases (MMPs) and increasing that of epidermal growth factor (EGF) and hyaluronan synthase (HAS) in the skin. These results indicate that AVGP supplementation prevents skin damage induced by UVB irradiation and ovariectomy in part by inhibiting damage to the extracellular matrix.
ISSN:0022-1147
1750-3841
DOI:10.1111/1750-3841.13527