Tumor targeting strategies for chitosan-based nanoparticles

[Display omitted] •Various chitosan-based derivatives as well as their advantages are illustrated.•The target mechanisms and key effect factors of passive-targeting are explained.•A systematic summary of targeting components are declared.•Chitosan-based stimuli-sensitive formulations are introduced....

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Bibliographic Details
Published in:Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2016-12, Vol.148, p.460-473
Main Authors: Zhang, Xingzhen, Yang, Xiaoye, Ji, Jianbo, Liu, Anchang, Zhai, Guangxi
Format: Article
Language:English
Subjects:
Anticancer properties
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - chemistry
Antineoplastic Agents - therapeutic use
Biomaterials
Carbohydrate Sequence
Cationic
Chitosan
Chitosan - chemistry
Derivatives
Drug Delivery Systems - methods
Effectiveness
Humans
Models, Biological
Molecular Targeted Therapy - methods
Nanoparticles
Nanoparticles - chemistry
Neoplasms - drug therapy
Neoplasms - pathology
Strategy
Targeted drug delivery
Tumor
Tumor Microenvironment - drug effects
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Summary:[Display omitted] •Various chitosan-based derivatives as well as their advantages are illustrated.•The target mechanisms and key effect factors of passive-targeting are explained.•A systematic summary of targeting components are declared.•Chitosan-based stimuli-sensitive formulations are introduced. Currently, targeted nanoparticles (NPs) are rapidly being developed to overcome various bottlenecks of antitumor agents, such as poor solubility in aqueous solution, poor pharmacokinetics, a lack of selectivity and undesirable side effects in healthy tissues. In recent years, chitosan, a cationic polysaccharide, has been widely explored for the targeted delivery of antitumor agents due to its unique physicochemical and biological properties, such as biocompatibility, biodegradability, mucoadhesive feature, absorption enhancement and active functional groups for chemical modifications. This article reviews the recent developments in various target-specific nanoparticles based on chitosan and its derivatives, including passive, active and stimuli-sensitive targeting strategies. In addition, the target mechanisms and the key efficacy factors are illuminated.
ISSN:0927-7765
1873-4367
DOI:10.1016/j.colsurfb.2016.09.020