Cytochrome P4501A expression, chemical contaminants and histopathology in roach, goby and sturgeon and chemical contaminants in sediments from the Caspian Sea, Lake Balkhash and the Ily River Delta, Kazakhstan

Roach, goby and sturgeon were examined for cytochrome P4501A (CYP1A) expression and histopathology, in relation to contaminant burdens in fish and sediment. Gradients of induction of CYP1A were observed. Roach from the Ural and Ily River Deltas and roach and goby from the two stations nearest the Ca...

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Bibliographic Details
Published in:Marine pollution bulletin 2003, Vol.46 (1), p.107-119
Main Authors: Moore, Michael J, Mitrofanov, Igor V, Valentini, Stefanie S, Volkov, Vjacheslav V, Kurbskiy, Aleksey V, Zhimbey, Elena N, Eglinton, Lorraine B, Stegeman, John J
Format: Article
Language:English
Subjects:
Acipenseridae
Agnatha. Pisces
Animal, plant and microbial ecology
Animals
Applied ecology
Biological and medical sciences
Biomarkers
Caspian Sea
CYP1A protein
Cytochrome P-450 CYP1A1 - biosynthesis
Cytochrome P450
Ecotoxicology, biological effects of pollution
Effects of pollution and side effects of pesticides on vertebrates
Environmental Exposure
Environmental impact
Enzyme Induction
Fish
Fishes - physiology
Fundamental and applied biological sciences. Psychology
Geologic Sediments - chemistry
Gobiidae
Kazakhstan
Kazakhstan, Balkhash L
Kazakhstan, Ily R
Pollution monitoring
Rutilus rutilus
Sublethal effects
Water Pollutants - adverse effects
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Summary:Roach, goby and sturgeon were examined for cytochrome P4501A (CYP1A) expression and histopathology, in relation to contaminant burdens in fish and sediment. Gradients of induction of CYP1A were observed. Roach from the Ural and Ily River Deltas and roach and goby from the two stations nearest the Caspian Sea oil fields displayed higher levels of CYP1A expression in several organs than was observed in fish from further offshore. Great sturgeon and Russian sturgeon showed higher levels of CYP1A expression than was seen in starred sturgeon and gobies in the Ural delta. No fish showed evidence of contaminant-related histopathologies in the organs examined, despite the elevated CYP1A levels. Low levels of polychlorinated biphenyls and elevated levels of inshore and riverine petroleum hydrocarbons from these habitats suggest that this ongoing hydrocarbon exposure, and that from natural sources and long-term oil exploration on the Northeastern Caspian shore, contributed to the CYP1A induction observed.
ISSN:0025-326X
1879-3363
DOI:10.1016/S0025-326X(02)00325-9