Cannabis use, COMT, BDNF and age at first-episode psychosis

Abstract Although an interaction between COMT Val158Met and BDNF Val66Met polymorphisms with cannabis use has been proposed with respect to the risk of psychosis emergence, findings remain inconclusive. The aim of the present study was to evaluate the different possible associations between these po...

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Bibliographic Details
Published in:Psychiatry research 2017-04, Vol.250, p.38-43
Main Authors: Mané, Anna, Bergé, Daniel, Penzol, Maria Jose, Parellada, Mara, Bioque, Miquel, Lobo, Antonio, Gonzalez-Pinto, Ana, Corripio, Iluminada, Cabrera, Bibiana, Sanchez-Torres, Ana Maria, Saiz, Jerónimo, Bernardo, Miguel
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Age of Onset
Alleles
Brain-Derived Neurotrophic Factor - genetics
Cannabis
Catechol O-Methyltransferase - genetics
Child
Female
Gender
Genetic Predisposition to Disease
Humans
Male
Marijuana Smoking - genetics
Polymorphism
Polymorphism, Single Nucleotide
Psychiatry
Psychotic Disorders - genetics
Schizophrenia
Sex Characteristics
Young Adult
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Summary:Abstract Although an interaction between COMT Val158Met and BDNF Val66Met polymorphisms with cannabis use has been proposed with respect to the risk of psychosis emergence, findings remain inconclusive. The aim of the present study was to evaluate the different possible associations between these polymorphisms and early cannabis use and the age at the first episode of psychosis. The relationship between age at psychosis onset and COMT Val158Met and BDNF Val66Met polymorphisms with early cannabis use as well as those factors associated with early cannabis use were investigated. Among 260 Caucasian first-episode psychosis patients, early cannabis use and the presence of the met-allele from the BDNF Val66Met polymorphism were significantly associated with age at psychosis onset. Furthermore, early cannabis use was significantly associated with male gender in the logistic regression analysis. These findings provide evidence of the important role of early cannabis use and the Val66Met BDNF polymorphism on age at psychosis onset and they point out to sex-specific differences in cannabis use patterns.
ISSN:0165-1781
1872-7123
DOI:10.1016/j.psychres.2017.01.045