Plant extracts: initial screening, identification of bioactive compounds and effect against Candida albicans biofilms

This study screened plants from Brazilian Pantanal for Candida albicans antibiofilm activity. Sixty extracts were obtained from ten plants using different extraction methods. Antifungal activity was assessed. Effects on biofilm inhibition and disruption and cytotoxicity were also evaluated. The most...

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Bibliographic Details
Published in:Future microbiology 2017-01, Vol.12 (1), p.15-27
Main Authors: Brighenti, Fernanda Lourenção, Salvador, Marcos José, Gontijo, Aline Vidal Lacerda, Delbem, Alberto Carlos Botazzo, Delbem, Ádina Cléia Botazzo, Soares, Cristina Pacheco, de Oliveira, Maria Alcionéiac Carvalho, Girondi, Camila Miorelli, Koga-Ito, Cristiane Yumi
Format: Article
Language:English
Subjects:
Acids
Antifungal activity
Antifungal agents
Antifungal Agents - pharmacology
Bioactive compounds
Biofilms
Biofilms - drug effects
Biological activity
Brazil
Buchenavia
Caco-2 Cells
Candida albicans
Candida albicans - drug effects
Combretaceae - chemistry
Cytotoxicity
Drugs
Ellagic acid
Ellagic Acid - pharmacology
Ethanol
Experiments
Gallic Acid - pharmacology
Humans
Phenols
Phenols - pharmacology
Plant extracts
Plant Extracts - pharmacology
Standard deviation
Variance analysis
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Summary:This study screened plants from Brazilian Pantanal for Candida albicans antibiofilm activity. Sixty extracts were obtained from ten plants using different extraction methods. Antifungal activity was assessed. Effects on biofilm inhibition and disruption and cytotoxicity were also evaluated. The most active extract was chemically characterized. Buchenavia tomentosa ethanolic extract showed noticeable antifungal activity and was selected for biofilm experiments. Subinhibitory concentration of extract inhibited fungal adhesion. Maximum killing reached 90% of C. albicans cells in suspension and 65% of cells in biofilms. The active extract was noncytotoxic. Chemical characterization showed the presence of phenols. Ellagic and gallic acids showed activity on C. albicans. B. tomentosa extract and its isolated compound, ellagic acid, presented antibiofilm activity and low toxicity.
ISSN:1746-0913
1746-0921
DOI:10.2217/fmb-2016-0094