A re-assessment of styrene-induced clastogenicity in mice in a subacute inhalation study

To date, a number of in vivo cytogenetic assays have studied the clastogenicity (chromosome aberrations, micronuclei formation) in bone marrow of rodents exposed to styrene by various routes. The majority of all these cytogenetic experiments yielded negative findings (Scott and Preston, Mutat Res 31...

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Bibliographic Details
Published in:Archives of toxicology 2003, Vol.77 (1), p.56-61
Main Authors: ENGELHARDT, Günter, GAMER, Armin, VODICKA, Pavel, BARTA, Ivo, HOFFMANN, Hans-Dieter, VEENSTRA, Gauke
Format: Article
Language:English
Subjects:
Administration, Inhalation
Animals
Biological and medical sciences
Bone Marrow Cells - drug effects
Chemical and industrial products toxicology. Toxic occupational diseases
Dose-Response Relationship, Drug
Erythrocytes - drug effects
Male
Medical sciences
Mice
Micronuclei, Chromosome-Defective - drug effects
Micronucleus Tests
Mutagenesis
Mutagens - administration & dosage
Mutagens - toxicity
Single-Blind Method
Solvents
Styrene - administration & dosage
Styrene - toxicity
Toxicology
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Summary:To date, a number of in vivo cytogenetic assays have studied the clastogenicity (chromosome aberrations, micronuclei formation) in bone marrow of rodents exposed to styrene by various routes. The majority of all these cytogenetic experiments yielded negative findings (Scott and Preston, Mutat Res 318:175-203, 1994). Recently published data from a micronucleus test in mice exposed via inhalation for up to 21 days showed some positive response, but was not fully conclusive (Vodicka et al., Chem Biol Interact 137:213-227, 2001). Since this exposure regimen has considerable relevance for workplace exposure, the present study was performed to further elucidate these findings. NMRI mice were exposed by whole body inhalation to styrene concentrations of 750 mg/m3 and 1,500 mg/m3 for 1, 3, 7, 14 and 21 consecutive days (6 h/day). Animals were killed directly after exposure and bone marrow was sampled for analysis of micronucleus induction. Under the experimental conditions used in the present investigation, there was no evidence of clastogenicity at any concentration or exposure interval.
ISSN:0340-5761
1432-0738
DOI:10.1007/s00204-002-0406-y