The Emerging Role of Cables1 in Cancer and Other Diseases

Cdk5 and Abl enzyme substrate 1 (Cables1) is an adaptor protein that links cyclin-dependent kinase (Cdks) with nonreceptor tyrosine kinases and regulates the activity of Cdks by enhancing their Y15 phosphorylation. Emerging evidence also shows that Cables1 can interact with, for example, p53 family...

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Bibliographic Details
Published in:Molecular pharmacology 2017-09, Vol.92 (3), p.240-245
Main Authors: Huang, Jia-Rong, Tan, Guang-Mou, Li, Yong, Shi, Zhi
Format: Article
Language:English
Subjects:
Animals
Carrier Proteins - chemistry
Carrier Proteins - genetics
Carrier Proteins - physiology
Cyclins - chemistry
Cyclins - genetics
Cyclins - physiology
Humans
Neoplasms - therapy
Phosphoproteins - chemistry
Phosphoproteins - genetics
Phosphoproteins - physiology
Phosphorylation
Tumor Suppressor Protein p53 - physiology
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Summary:Cdk5 and Abl enzyme substrate 1 (Cables1) is an adaptor protein that links cyclin-dependent kinase (Cdks) with nonreceptor tyrosine kinases and regulates the activity of Cdks by enhancing their Y15 phosphorylation. Emerging evidence also shows that Cables1 can interact with, for example, p53 family proteins, 14-3-3, and -catenin, suggesting that Cables1 may be a signaling hub for the regulation of cell growth. Abnormal expression of Cables1 has been observed in multiple types of cancers and other diseases. In this review, we summarize the characteristics of Cables1 and highlight the molecular mechanisms through which Cables1 regulates the development of cancer and other diseases. Finally, we discuss future challenges in demonstrating the role and potential application of Cables1 in cancer and other diseases.
ISSN:0026-895X
1521-0111
DOI:10.1124/mol.116.107730