Transient Neonatal Zinc Deficiency Caused by a Novel Mutation in the SLC30A2 Gene

This is a case report of a 4‐month‐old full‐term, fully breastfed boy who presented with a persistent periorificial and groin rash associated with poor weight gain and irritability. His serum zinc level was low. The mother's breast milk zinc level was found to be low despite her serum zinc leve...

Full description

Saved in:
Bibliographic Details
Published in:Pediatric dermatology 2017-03, Vol.34 (2), p.e104-e105
Main Authors: Liew, Hui M., Tan, Colin W., Ho, Clement K. M., Chee, Jade N., Koh, Mark J. A.
Format: Article
Language:English
Subjects:
Breast milk
Cation Transport Proteins - genetics
Epithelial cells
Exanthema
Growth Disorders - genetics
Growth Disorders - pathology
Humans
Infant
Male
Mammary gland
Milk
Milk, Human - chemistry
Mutation
Mutation - genetics
Neonates
Newborn babies
Nutrient deficiency
Zinc
Zinc - deficiency
Zinc transporter
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This is a case report of a 4‐month‐old full‐term, fully breastfed boy who presented with a persistent periorificial and groin rash associated with poor weight gain and irritability. His serum zinc level was low. The mother's breast milk zinc level was found to be low despite her serum zinc levels being normal, confirming the diagnosis of transient neonatal zinc deficiency. Mutational analysis revealed a novel mutation in the mother's SLC30A2 gene, which encodes a zinc transporter expressed in mammary gland epithelial cells.
ISSN:0736-8046
1525-1470
DOI:10.1111/pde.13065