Responses of the rotifer Brachionus plicatilis to flame retardant (BDE-47) stress

A series of short-term toxicological tests were conducted on the rotifer Brachionus plicatilis to assess the toxicity of the flame retardant 2,2′,4,4′-tetrabrominated biphenyl ether (BDE-47). BDE-47 increased mortality, morphological damage, and altered population dynamics and fecundity of rotifer....

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Bibliographic Details
Published in:	Marine pollution bulletin 2017-03, Vol.116 (1-2), p.298-306
Main Authors:	Jian, Xiaoyang, Tang, Xuexi, Xu, Ningning, Sha, Jingjing, Wang, You
Format:	Article
Language:	eng
Subjects:	2,2′,4,4′-Tetrabromodiphenyl ether (BDE-47) Animals Antioxidant enzymatic system Antioxidants - metabolism Brachionus plicatilis Flame Retardants - toxicity Glutathione - metabolism Halogenated Diphenyl Ethers - toxicity Marine zooplankton Oxidative Stress Reactive oxygen species (ROS) Reactive Oxygen Species - metabolism Rotifera - drug effects Toxicity Tests Water Pollutants, Chemical - toxicity Xenobiotic-metabolizing enzymatic system
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Summary:	A series of short-term toxicological tests were conducted on the rotifer Brachionus plicatilis to assess the toxicity of the flame retardant 2,2′,4,4′-tetrabrominated biphenyl ether (BDE-47). BDE-47 increased mortality, morphological damage, and altered population dynamics and fecundity of rotifer. Antioxidant enzymes were differentially changed to maintain the balance between antioxidant and pro-oxidant activity. However, with increases in the concentration of BDE-47, the metabolic and antioxidant activity decreased. Moreover, the reactive oxygen species (ROS) and malondialdehyde contents increased and the ratio between glutathione and glutathione-SH decreased, indicating oxidative stress. The addition of the ROS-inhibitor N-acetylcysteine alleviated the degree of damage and stimulated the activity of xenobiotic-metabolizing and antioxidant system, which suggested that ROS were the most important loop in the stress response. •Responses of xenobiotic-metabolizing and antioxidant system to BDE-47 were assessed in rotifer.•Activated Phase I could orderly stimulate Phase II to accelerate the detoxification.•Main components of antioxidant system changed at different levels.•Population dynamic and reproduction varied with detoxifying system and ROS production.•NAC addition implied ROS were the most essential loop in the stress induced by BDE-47.
ISSN:	0025-326X 1879-3363