Brain Barrier Breakdown as a Cause and Consequence of Neuroinflammation in Sepsis

The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB) are important for the maintenance of brain homeostasis . During sepsis, peripheral production of proinflammatory cytokines and reactive oxygen species are responsible for structural alterations in those brain barriers. T...

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Bibliographic Details
Published in:Molecular neurobiology 2018-02, Vol.55 (2), p.1045-1053
Main Authors: Danielski, Lucineia Gainski, Giustina, Amanda Della, Badawy, Marwa, Barichello, Tatiana, Quevedo, João, Dal-Pizzol, Felipe, Petronilho, Fabrícia
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Blood-brain barrier
Blood-Brain Barrier - metabolism
Blood-Brain Barrier - pathology
Brain injury
Cell Biology
Cerebrospinal fluid
Cytokines
Cytotoxicity
Encephalitis - metabolism
Encephalitis - pathology
Glial cells
Homeostasis
Humans
Inflammation
Microglia
Microglia - metabolism
Microglia - pathology
Neurobiology
Neurology
Neurosciences
Permeability
Reactive oxygen species
Review
Sepsis
Sepsis - metabolism
Sepsis - pathology
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Summary:The blood-brain barrier (BBB) and the blood-cerebrospinal fluid barrier (BCSFB) are important for the maintenance of brain homeostasis . During sepsis, peripheral production of proinflammatory cytokines and reactive oxygen species are responsible for structural alterations in those brain barriers. Thus, an increasing permeability of these barriers can lead to the activation of glial cells such as microglia and the production of cytotoxic mediators which in turn act on the brain barriers, damaging them further. Thereby, in this review, we try to highlight how the brain barrier’s permeability is not only a cause but a consequence of brain injury in sepsis.
ISSN:0893-7648
1559-1182
DOI:10.1007/s12035-016-0356-7