Toxicity and Larvicidal Activity of Podophyllum-Based Lignans Against Aedes aegypti (Diptera: Culicidae)

Aedes aegypti L. (Diptera: Culicidae) is a mosquito species that has adapted to urban environments and is the main vector of dengue viruses. Because of the increasing incidence of dengue, a more environmentally acceptable insecticide needs to be found. Natural products have been and continue to be a...

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Bibliographic Details
Published in:Journal of medical entomology 2017-01, Vol.54 (1), p.159-166
Main Authors: Maleck, Marise, Hollanda, Priscila de Oliveira, Serdeiro, Michele Teixeira, Soares, Renata Oliveira de Araújo, Honório, Nildimar Alves, Silva, Cláudia Gontijo
Format: Article
Language:English
Subjects:
Acetone
Aedes aegypti
Aquatic plants
Biological activity
Culicidae
Dengue fever
Dilution
Diptera
Insecticides
Larvae
larvicidal activity
Lignans
Mosquitoes
Natural products
Podophyllotoxin
Podophyllum hexandrum
Rhizomes
Roots
Toxicity
Urban environments
VECTOR CONTROL, PEST MANAGEMENT, RESISTANCE, REPELLENTS
Vector-borne diseases
Viruses
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Summary:Aedes aegypti L. (Diptera: Culicidae) is a mosquito species that has adapted to urban environments and is the main vector of dengue viruses. Because of the increasing incidence of dengue, a more environmentally acceptable insecticide needs to be found. Natural products have been and continue to be an important source of leading compounds that can be modified in order to develop new drugs. The lignan family of natural products includes compounds with a diverse spectrum of biological activity. Podophyllotoxin and its related lignans represent an exciting class of natural products that can be targeted at different types of biological activity and are therefore worth exploring further. This study had the aim of evaluating the larvicidal activity of an ethanolic extract from the rhizomes and roots of Podophyllum hexandrum (PM-3) and its isolated lignans, podophyllotoxone (1) and desoxypodophyllotoxin (2), on the larvae of the mosquito vector Ae. aegypti. The PM-3 extract and the compounds (1) and (2) were dissolved in a mixture of acetone and dimethylsulfoxide at final concentrations of 1, 10, 30, 50, 100, and 200 μg/ml. After dilution, the solutions were applied (μg/ml) to the larvae-rearing medium. Overall, the ethanolic extract from the rhizomes and roots of P. hexandrum and the compounds (1) and (2) showed larvicidal activity against the larvae of Ae. aegypti. According to the results from this study, it can be concluded that podophyllotoxone (1) and desoxypodophyllotoxin (2) exhibited significant toxicity toward Ae. aegypti larvae.
ISSN:0022-2585
0022-2858
1938-2928
DOI:10.1093/jme/tjw130