Effect of osteoporosis on fixation of osseointegrated implants in rats

The effect of osteoporosis on implant osseointegration has been widely investigated, whereas osteoporosis may also newly occur in patient with previously osseointegrated implant. This study was designed to investigate the effect of osteoporosis on implant fixation in rats after successful osseointeg...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2017-11, Vol.105 (8), p.2426-2432
Main Authors: Li, Yunfeng, He, Sheng, Hua, Yunwei, Hu, Jing
Format: Article
Language:English
Subjects:
Animals
Biocompatibility
Biomechanical engineering
Biomechanics
Biomedical materials
Bone implants
Bone-Implant Interface
Cancellous bone
Computed tomography
Destructive testing
Female
Femur
Femur - diagnostic imaging
Femur - metabolism
Fixation
Histology
Implants, Experimental
Materials research
Materials science
Mechanical properties
Metaphysis
Osseointegration
Osteoporosis
Osteoporosis - diagnostic imaging
Osteoporosis - metabolism
Osteoporosis - pathology
Ovariectomy
Rats
Rats, Sprague-Dawley
Rodents
Studies
Surgical implants
Transplants & implants
X-Ray Microtomography
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Summary:The effect of osteoporosis on implant osseointegration has been widely investigated, whereas osteoporosis may also newly occur in patient with previously osseointegrated implant. This study was designed to investigate the effect of osteoporosis on implant fixation in rats after successful osseointegration had been obtained. Seventy female Sprague-Dawley rats were included, and each animal received two titanium implants in the distal metaphysis of femur bilaterally. Eight weeks later, ten rats were sacrificed to confirm the establishment of implant osseointegration. All left rats were randomly subjected to bilateral ovariectomy (OVX) or sham operation. Three, six, and twelve weeks later, implant osseointegration, peri-implant bone tissue, and biomechanical properties of implant were analyzed. Right femurs with implants were used for micro-CT and histological analysis, and left femurs with implants were used for biomechanical test. Micro-CT, histology, and biomechanical test confirmed the destructive effect of OVX on previously osseointegrated implant in rats; when compared to sham-operated rats, peri-implant bone volume, trabecular architecture, bone-to-implant contact ratio, as well as biomechanical parameters decreased progressively within 12 weeks. Results also indicated that the effect of OVX on undisturbed bone (proximal tibiae) was much stronger than that on peri-implant bone. Osteoporosis produced a progressive negative effect on previously osseointegrated implant in distal femora of rats during 12 weeks. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 2426-2432, 2017.
ISSN:1552-4973
1552-4981
DOI:10.1002/jbm.b.33787