Enlarged perivascular spaces and cognitive impairment after stroke and transient ischemic attack

Background Previous studies suggested that enlarged perivascular spaces are neuroimaging markers of cerebral small vessel disease. However, it is not clear whether enlarged perivascular spaces are associated with cognitive impairment. We aimed to determine the cross-sectional relationship between en...

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Bibliographic Details
Published in:International journal of stroke 2018-01, Vol.13 (1), p.47-56
Main Authors: Arba, Francesco, Quinn, Terence J, Hankey, Graeme J, Lees, Kennedy R, Wardlaw, Joanna M, Ali, Myzoon, Inzitari, Domenico
Format: Article
Language:English
Subjects:
Aged
Basal Ganglia - diagnostic imaging
Basal Ganglia - pathology
Cognitive Dysfunction - complications
Cognitive Dysfunction - pathology
Cross-Sectional Studies
Extracellular Space - diagnostic imaging
Female
Humans
Ischemic Attack, Transient - complications
Ischemic Attack, Transient - diagnostic imaging
Ischemic Attack, Transient - pathology
Magnetic Resonance Imaging
Male
Middle Aged
Neuroimaging
Stroke - complications
Stroke - diagnostic imaging
Stroke - pathology
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Summary:Background Previous studies suggested that enlarged perivascular spaces are neuroimaging markers of cerebral small vessel disease. However, it is not clear whether enlarged perivascular spaces are associated with cognitive impairment. We aimed to determine the cross-sectional relationship between enlarged perivascular spaces and small vessel disease, and to investigate the relationship between enlarged perivascular spaces and subsequent cognitive impairment in patients with recent cerebral ischemic event. Methods Anonymized data were accessed from the virtual international stroke trial archive. We rated number of lacunes, white matter hyperintensities, brain atrophy, and enlarged perivascular spaces with validated scales on magnetic resonance brain images after the index stroke. We defined cognitive impairment as a mini mental state examination score of ≤26, recorded at one year post stroke. We examined the associations between enlarged perivascular spaces and clinical and imaging markers of small vessel disease at presentation and clinical evidence of cognitive impairment at one year using linear and logistic regression models. Results We analyzed data on 430 patients with mean (±SD) age 64.7 (±12.7) years, 276 (64%) males. In linear regression analysis, age (β = 0.24; p 
ISSN:1747-4930
1747-4949
DOI:10.1177/1747493016666091