Unexpected reaction of new HAp/glucan composite to environmental acidification: Defect or advantage?

Natural polymer-based composites become very popular in design of biomaterials for bone tissue regeneration. Their rheological and mechanical properties are typically evaluated in vitro according to standard methods. However, in vivo such composites may behave completely different due to specific bo...

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Bibliographic Details
Published in:Journal of biomedical materials research. Part B, Applied biomaterials Applied biomaterials, 2017-07, Vol.105 (5), p.1178-1190
Main Authors: Borkowski, Leszek, Kiernicka, Małgorzata, Belcarz, Anna, Pałka, Krzysztof, Hajnos, Mieczysław, Ginalska, Grażyna
Format: Article
Language:English
Subjects:
Acidification
Alveoli
Augmentation
beta-Glucans - chemistry
Biomaterials
Biomedical materials
Bone biomaterials
Ceramics
Clinical trials
Composite materials
Computed tomography
Design
Design analysis
Design defects
Durapatite - chemistry
Extraction
Glucan
Hydrogen-Ion Concentration
Hydroxyapatite
Implantation
In vitro methods and tests
In vivo methods and tests
Intrusion
Liquids
Loosening
Materials research
Materials science
Mechanical properties
Mercury
Phase transitions
Polymer matrix composites
Pore size
Porosity
Regeneration
Side effects
Soaking
Surgical implants
Swelling
Volume measurement
Wounds
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Summary:Natural polymer-based composites become very popular in design of biomaterials for bone tissue regeneration. Their rheological and mechanical properties are typically evaluated in vitro according to standard methods. However, in vivo such composites may behave completely different due to specific body conditions (e.g., inflammation-assisted acidification of tissue liquids). Such surprising phenomenon was observed for hydroxyapatite/β-1, 3-glucan composite during alveolus extraction socket augmentation in people. Implanted composite showed unexpected massive swelling, caused stitches loosening and wound reopening 5 days after implantation. Acidic pH was selected as a potential factor affecting this phenomenon, as all implantations are accompanied by transient local inflammation and acidification. Composite parameters were therefore studied after 5 days of soaking in acidic medium by weight and volume measurement, SEM, XRD, FTIR, microCT, and mercury intrusion techniques. Results showed significant volume increase, pore size remodelling and ceramic phase rearrangement in the composite, accompanied by change of mechanical properties. Simple quantitative correction of amount of implanted composite was sufficient to control in vivo appearance of side effects, confirming that pH-related volume increase of HAp/glucan composite is not a disqualifying factor. This strongly suggests the necessity of very detailed and individually designed tests concerning all new polymer-based composite biomaterials before clinical trials. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1178-1190, 2017.
ISSN:1552-4973
1552-4981
DOI:10.1002/jbm.b.33646