Impaired Bone Microarchitecture Improves After One Year On Gluten‐Free Diet: A Prospective Longitudinal HRpQCT Study in Women With Celiac Disease

ABSTRACT We have recently identified a significant deterioration of bone microarchitecture in premenopausal women with newly diagnosed celiac disease (CD) using high‐resolution peripheral quantitative computed tomography (HRpQCT). The aim of this work was to assess changes in bone microarchitecture...

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Bibliographic Details
Published in:Journal of bone and mineral research 2017-01, Vol.32 (1), p.135-142
Main Authors: Zanchetta, María Belén, Longobardi, Vanesa, Costa, Florencia, Longarini, Gabriela, Mazure, Roberto Martín, Moreno, María Laura, Vázquez, Horacio, Silveira, Fernando, Niveloni, Sonia, Smecuol, Edgardo, de la Paz Temprano, María, Massari, Fabio, Sugai, Emilia, González, Andrea, Mauriño, Eduardo César, Bogado, Cesar, Zanchetta, José R, Bai, Julio César
Format: Article
Language:English
Subjects:
Absorptiometry, Photon
Adult
Bone and Bones - diagnostic imaging
Bone and Bones - pathology
Bone Density
BONE DISORDERS
BONE MICROARCHITECTURE
Calcium - metabolism
Case-Control Studies
CELIAC DISEASE
Celiac Disease - diet therapy
Celiac Disease - pathology
Demography
Diet, Gluten-Free
Dietary Supplements
Female
FRACTURES
GLUTEN‐FREE DIET
HRpQCT
Humans
Longitudinal Studies
Middle Aged
OSTEOPOROSIS
Patient Compliance
Prospective Studies
Tomography, X-Ray Computed
Vitamin D - therapeutic use
Young Adult
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Summary:ABSTRACT We have recently identified a significant deterioration of bone microarchitecture in premenopausal women with newly diagnosed celiac disease (CD) using high‐resolution peripheral quantitative computed tomography (HRpQCT). The aim of this work was to assess changes in bone microarchitecture after 1 year on a gluten‐free diet (GFD) in a cohort of premenopausal women. We prospectively enrolled 31 consecutive females at diagnosis of CD; 26 of them were reassessed 1 year after GFD. They all underwent HRpQCT scans of distal radius and tibia, areal BMD by DXA, and biochemical tests (bone‐specific parameters and CD serology) at both time points. Secondary, we compared 1‐year results with those of a control group of healthy premenopausal women of similar age and BMI in order to assess whether the microarchitectural parameters of treated CD patients had reached the values expected for their age. Compared with baseline, the trabecular compartment in the distal radius and tibia improved significantly (trabecular density, trabecular/bone volume fraction [BV/TV] [p 
ISSN:0884-0431
1523-4681
DOI:10.1002/jbmr.2922