A novel multisystem disease associated with recessive mutations in the tyrosyl‐tRNA synthetase (YARS) gene

Aminoacyl‐tRNA synthetases (ARSs) are a group of ubiquitously expressed enzymes that are best known for their function in the first step of protein translation but have been increasingly associated with secondary functions including transcription and translation control and extracellular signaling....

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Bibliographic Details
Published in:American journal of medical genetics. Part A 2017-01, Vol.173 (1), p.126-134
Main Authors: Nowaczyk, Małgorzata J. M., Huang, Lijia, Tarnopolsky, Mark, Schwartzentruber, Jeremy, Majewski, Jacek, Bulman, Dennis E., Hartley, Taila, Boycott, Kym M.
Format: Article
Language:English
Subjects:
Alleles
aminoacylation
exome sequencing
Facies
Genes, Dominant
Genetic Association Studies
Genetic Diseases, Inborn - diagnosis
Genetic Diseases, Inborn - genetics
Genotype
hepatic cirrhosis
Humans
Infant
Magnetic Resonance Imaging
Male
Models, Molecular
Mutation
Pedigree
Phenotype
Protein Conformation
pulmonary cysts
Sequence Analysis, DNA
Siblings
Tomography, X-Ray Computed
Tyrosine-tRNA Ligase - chemistry
Tyrosine-tRNA Ligase - genetics
tyrosyl‐tRNA synthetase
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Summary:Aminoacyl‐tRNA synthetases (ARSs) are a group of ubiquitously expressed enzymes that are best known for their function in the first step of protein translation but have been increasingly associated with secondary functions including transcription and translation control and extracellular signaling. Mutations in numerous ARSs have been linked to a growing number of both autosomal dominant and autosomal recessive human diseases. The tyrosyl‐tRNA synthetase (YARS) links the amino acid tyrosine to its cognate tRNA. We report two siblings who presented with failure to thrive (FTT), hypertriglyceridemia, developmental delay, liver dysfunction, lung cysts, and abnormal subcortical white matter. Using exome sequencing the siblings were found to harbor bi‐allelic pathogenic‐appearing variants within the YARS gene (NM_003680.3):c.638C>T p.(Pro213Leu) and c.1573G>A p.(Gly525Arg). These YARS variants occur in the catalytic domain and the C‐terminal domain, respectively. Mutations in YARS have been previously associated with an autosomal dominant form of Charcot‐Marie‐Tooth (CMT); our findings suggest the disease spectrum associated with YARS dysregulation is broader than peripheral neuropathy. © 2016 Wiley Periodicals, Inc.
ISSN:1552-4825
1552-4833
DOI:10.1002/ajmg.a.37973