Changes in the receptor activity of beta sub(2)-adrenoreceptors of human T-lymphocytes under the effect of beta sub(2)-agonists

Changes in the activity of beta sub(2)-adrenergic receptors of human T-lymphocytes under the effect of salbutamol (a short-acting beta sub(2)-agonist) have been evaluated with a new modified radioligand method utilizing [ super(125)I]cyanopindolol and a specific ligand ICI 118551. In healthy volunte...

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Bibliographic Details
Published in:Molecular biology (New York) 2016-11, Vol.50 (6), p.880-886
Main Authors: Agapova, O Y, Skoblov, Y S, Tkachev, G A, Mironova, NA, Golitsyn, S P, Masenko, V P, Chazova, I E, Zykov, KA
Format: Article
Language:English
Online Access:Get full text
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Summary:Changes in the activity of beta sub(2)-adrenergic receptors of human T-lymphocytes under the effect of salbutamol (a short-acting beta sub(2)-agonist) have been evaluated with a new modified radioligand method utilizing [ super(125)I]cyanopindolol and a specific ligand ICI 118551. In healthy volunteers, the receptor activity decreased after 30 min upon the inhalation of salbutamol and restored to the initial level after 2 h. At the same time, there were changes in the transcription level of the ADRB2 gene, which encodes the protein component of the beta sub(2)-adrenoreceptor. The dynamics of beta sub(2)-adrenergic receptor activity of T-lymphocytes after salbutamol treatment in patients with cardiorespiratory pathology significantly differed from that in healthy volunteers.
ISSN:0026-8933
1608-3245
DOI:10.1134/S0026893316050022