Cortisol during human fetal life: Characterization of a method for processing small quantities of newborn hair from 26 to 42 weeks gestation

OBJECTIVE Fetal cortisol may be reflected in hair collected shortly after birth. The objective of this study was to determine the range of human fetal hair cortisol concentrations (HCC) in live‐born neonates using an approach for processing small quantities of hair. MATERIALS AND METHODS Hair was cu...

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Published in:Developmental psychobiology 2017-01, Vol.59 (1), p.123-127
Main Authors: Hoffman, M. Camille, D'Anna‐Hernandez, Kimberly, Benitez, Patrick, Ross, Randal G., Laudenslager, Mark L.
Format: Article
Language:English
Subjects:
Adult
Female
fetal hair cortisol
Fetus - metabolism
Gestational Age
Hair - chemistry
Humans
Hydrocortisone - metabolism
infant hair cortisol
Infant, Newborn
Infant, Premature
Male
Pregnancy - metabolism
Young Adult
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Summary:OBJECTIVE Fetal cortisol may be reflected in hair collected shortly after birth. The objective of this study was to determine the range of human fetal hair cortisol concentrations (HCC) in live‐born neonates using an approach for processing small quantities of hair. MATERIALS AND METHODS Hair was cut on the day of birth from neonates and their mothers, born between 26 and 42 weeks gestational age (GA). HCC was determined by enzyme immunoassay. Maternal sociodemographics and birth data were collected. T‐tests, ANOVA, Pearson correlation, and Wilcoxon Signed Rank test were used as appropriate. RESULTS Ninety maternal and neonatal hair samples were cut from 79 term (T) and 11 preterm (PT) delivered pregnancies. All samples weighed ≥2.5 mg. Fetal HCC correlated with GA (r = .25, p = .02) and birth weight (r = .25, p = .03) and was lower in PT (4.3 ± .3 LN pg/mg) than T (5.3 ± .1, LN pg/mg, p 
ISSN:0012-1630
1098-2302
DOI:10.1002/dev.21433