Impact of stereotactic radiosurgery dose on control of cerebral metastases from renal cell carcinoma

Renal cell carcinoma (RCC) is a relatively radioresistant tumor and may require for higher radiation doses than other tumor types. Nineteen patients treated with 20 Gy of stereotactic radiosurgery (SRS) alone for one to three cerebral metastases were compared to nine patients treated with 16-18 Gy....

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Bibliographic Details
Published in:Anticancer research 2015-06, Vol.35 (6), p.3571-3574
Main Authors: Rades, Dirk, Huttenlocher, Stefan, Gebauer, Niklas, Hornung, Dagmar, Trang, Ngo Thuy, Khoa, Mai Trong, Schild, Steven E
Format: Article
Language:English
Subjects:
Aged
Brain Neoplasms - pathology
Brain Neoplasms - secondary
Carcinoma, Renal Cell - pathology
Carcinoma, Renal Cell - radiotherapy
Female
Humans
Kaplan-Meier Estimate
Karnofsky Performance Status
Male
Middle Aged
Neoplasms, Radiation-Induced - pathology
Neoplasms, Radiation-Induced - secondary
Proportional Hazards Models
Radiosurgery - adverse effects
Radiotherapy Dosage
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Summary:Renal cell carcinoma (RCC) is a relatively radioresistant tumor and may require for higher radiation doses than other tumor types. Nineteen patients treated with 20 Gy of stereotactic radiosurgery (SRS) alone for one to three cerebral metastases were compared to nine patients treated with 16-18 Gy. SRS with 20 Gy led to significantly better local control than did 16-18 Gy (81% vs. 50% at 12 months; p
ISSN:0250-7005
1791-7530