A new serum assay to measure N-terminal fragment of telopeptide of type I collagen in patients with renal osteodystrophy

Background: Up until now, there was little known about the use of bone resorption markers in the assessment of bone status in patients with chronic renal failure (CRF). The present study evaluated the ability of a new immunoassay for N-terminal telopeptide of type I collagen to assess bone turnover...

Full description

Saved in:
Bibliographic Details
Published in:European journal of internal medicine 2003-05, Vol.14 (3), p.172-177
Main Authors: Montagnani, A., Gonnelli, S., Cepollaro, C., Mangeri, M., Martini, S., Franci, M.B., Campagna, M.S., Lucani, B., Di Paolo, N., Bellucci, G., Gennari, C.
Format: Article
Language:English
Subjects:
Biochemical markers
Bone turnover
N-terminal telopeptide of type I collagen
Renal osteodystrophy
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: Up until now, there was little known about the use of bone resorption markers in the assessment of bone status in patients with chronic renal failure (CRF). The present study evaluated the ability of a new immunoassay for N-terminal telopeptide of type I collagen to assess bone turnover in a group of hemodialyzed patients. Methods: The following parameters were measured in a fasting blood sample from 111 patients on maintenance hemodialysis for at least 2 years and in 120 healthy subjects: calcium, phosphorus, magnesium, BALP, PTH, and N-terminal telopeptide of type I collagen (NTx—ELISA, OSTEOMARK NTx Siero-Ostex International). Results: Serum PTH, BALP, and NTx were significantly higher ( P
ISSN:0953-6205
1879-0828
DOI:10.1016/S0953-6205(03)00034-7