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Idiopathic and allergic rhinitis show a similar inflammatory response
Hypothesis. Idiopathic and allergic rhinitics have similar mucosal mast cell and IgE+ cell distribution. Introduction. The pathophysiology of idiopathic rhinitis (IR) is unknown but patients differ from those with allergic rhinitis (AR) in that they do not express IgE. Our study is novel because we...
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Published in: | Clinical otolaryngology and allied sciences 2000-12, Vol.25 (6), p.570-576 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Citations: | Items that cite this one |
Online Access: | Get full text |
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Summary: | Hypothesis. Idiopathic and allergic rhinitics have similar mucosal mast cell and IgE+ cell distribution.
Introduction. The pathophysiology of idiopathic rhinitis (IR) is unknown but patients differ from those with allergic rhinitis (AR) in that they do not express IgE. Our study is novel because we investigated: (1) three study groups chosen prospectively using strict selection criteria over a 4‐year period; and (2) mast cell and IgE+ cell counts were on full‐thickness, full‐length inferior turbinate mucosa.
Methods. Patient groups: allergic (n = 17); idiopathic: (n = 16); and normal controls (n = 9). Immunohistochemistry: mast cell and IgE+ cell detection using anti‐mast cell tryptase and anti‐IgE antibodies with an avidin‐biotin (peroxidase) complex on paraffin processed tissue. Morphometry: sections were divided into three strata comprising an epithelial layer and two submucosal layers. Statistics: Mann–Whitney non‐parametric analysis. α = 0.05, β = 0.2.
Results. The power of the study was 89%. Mast cells (P = 0.03) and IgE+ cells (P |
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ISSN: | 0307-7772 1365-2273 |
DOI: | 10.1046/j.1365-2273.2000.00422-2.x |