Facile lewis acid catalyzed synthesis of C(4) symmetric resorcinarenes

The Lewis acid catalyzed condensation of 3-methoxyphenol with octanal produced the C(4) symmetric calix[4]resorcinarene 2, in high yield. Of the numerous stereo- and regioisomers possible, the rccc isomer with C(4) symmetry was the only product isolated (as a racemate). The structure has been establ...

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Bibliographic Details
Published in:Organic letters 2000-11, Vol.2 (24), p.3869-3871
Main Authors: McIldowie, MJ, Mocerino, M, Skelton, BW, White, AH
Format: Article
Language:English
Online Access:Get full text
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Summary:The Lewis acid catalyzed condensation of 3-methoxyphenol with octanal produced the C(4) symmetric calix[4]resorcinarene 2, in high yield. Of the numerous stereo- and regioisomers possible, the rccc isomer with C(4) symmetry was the only product isolated (as a racemate). The structure has been established by single-crystal X-ray structure analysis.
ISSN:1523-7052