Acetamidoglycosylation with Glycal Donors: A One-Pot Glycosidic Coupling with Direct Installation of the Natural C(2)-N-Acetylamino Functionality

Nitrogen transfer to glycals: A new method for direct C2‐aza‐glycosylation with glycal donors has been developed (see scheme), employing the new reagent combination of thianthrene‐S‐oxide and trifluoroacetic anhydride for glycal activation, in an overall one‐pot procedure.

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Bibliographic Details
Published in:Angewandte Chemie (International ed.) 2000-01, Vol.39 (1), p.204-207
Main Authors: Di Bussolo, Valeria, Liu, Jing, Huffman, Jr, Larry G., Gin, David Y.
Format: Article
Language:English
Subjects:
carbohydrates
glycals
glycosylations
nitrogen transfer
Online Access:Get full text
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Summary:Nitrogen transfer to glycals: A new method for direct C2‐aza‐glycosylation with glycal donors has been developed (see scheme), employing the new reagent combination of thianthrene‐S‐oxide and trifluoroacetic anhydride for glycal activation, in an overall one‐pot procedure.
ISSN:1433-7851
1521-3773
DOI:10.1002/(SICI)1521-3773(20000103)39:1<204::AID-ANIE204>3.0.CO;2-Z