Physicochemical Study of Hydrophobic Derivatives of Collagen Fragments

Collagen fragments of molecular weights ranging from 700 to 3500 were prepared and allowed to react with hexyl and lauryl aldehydes in order to obtain derivatives of different hydrophobicities. Lauryl collagen forms, in aqueous solutions, aggregates that have low tendency to interact with phospholip...

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Bibliographic Details
Published in:Journal of colloid and interface science 1998-09, Vol.205 (1), p.141-148
Main Authors: Fonseca, M.J., Juvé, A., Lörincz, Z., Reig, F., Alsina, M.A.
Format: Article
Language:English
Subjects:
Analytical chemistry
Analytical, structural and metabolic biochemistry
ANS
Biological and medical sciences
Chemistry
collagen
Exact sciences and technology
fluorescence
Fundamental and applied biological sciences. Psychology
General, instrumentation
Glycoproteins
liposomes
phospholipid monolayers
protein alkylation
Proteins
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Summary:Collagen fragments of molecular weights ranging from 700 to 3500 were prepared and allowed to react with hexyl and lauryl aldehydes in order to obtain derivatives of different hydrophobicities. Lauryl collagen forms, in aqueous solutions, aggregates that have low tendency to interact with phospholipid mono and bilayers, with reduced surface activity but the ability to entrap ANS molecules. The hexyl derivative shows a greater hydrophobicity in terms of surface activity and interaction with lipids but a lower ability to incorporate ANS. Underivatized collagen shows no lipid interaction in any of the experiments.
ISSN:0021-9797
1095-7103
DOI:10.1006/jcis.1998.5642