Uveitis in childhood-onset systemic lupus erythematosus patients: a multicenter survey

The aim of this study is to assess uveitis prevalence in a large cohort of childhood-onset systemic lupus erythematosus (cSLE) patients. A retrospective multicenter cohort study including 852 cSLE patients was performed in ten pediatric rheumatology centers (Brazilian cSLE group). An investigator me...

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Bibliographic Details
Published in:Clinical rheumatology 2017-03, Vol.36 (3), p.547-553
Main Authors: Kahwage, Paola Pinheiro, Ferriani, Mariana Paes Leme, Furtado, João M., de Carvalho, Luciana Martins, Pileggi, Gecilmara Salviato, Gomes, Francisco Hugo Rodrigues, Terreri, Maria Teresa, Magalhães, Claudia Saad, Pereira, Rosa Maria Rodrigues, Sacchetti, Silvana Brasilia, Marini, Roberto, Bonfá, Eloisa, Silva, Clovis Artur, Ferriani, Virgínia Paes Leme
Format: Article
Language:English
Subjects:
Adolescent
Age of Onset
Brazil - epidemiology
Child
Comorbidity
Female
Humans
Lupus Erythematosus, Systemic - diagnosis
Lupus Erythematosus, Systemic - drug therapy
Lupus Erythematosus, Systemic - epidemiology
Male
Medicine
Medicine & Public Health
Methylprednisolone - therapeutic use
Original Article
Prevalence
Retrospective Studies
Rheumatology
Severity of Illness Index
Uveitis - diagnosis
Uveitis - epidemiology
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Summary:The aim of this study is to assess uveitis prevalence in a large cohort of childhood-onset systemic lupus erythematosus (cSLE) patients. A retrospective multicenter cohort study including 852 cSLE patients was performed in ten pediatric rheumatology centers (Brazilian cSLE group). An investigator meeting was held and all participants received database training. Uveitis was diagnosed through clinical assessment by the uveitis expert ophthalmologist of each center. Patients with and without uveitis were assessed for lupus clinical/laboratory features and treatments. Uveitis was observed in 7/852 cSLE patients (0.8%). Two of them had ocular complications: cataract and irreversible blindness in one patient and retinal ischemia with subsequent neovascularization and unilateral blindness in another. Uveitis was identified within the first 6 months of cSLE diagnosis in 6/7 patients (86%). Comparison of a subgroup of cSLE patients with ( n  = 7) and without uveitis ( n  = 73) and similar length of disease duration showed that patients with uveitis had increased SLEDAI-2K score (19 vs. 6; p  
ISSN:0770-3198
1434-9949
DOI:10.1007/s10067-016-3534-0