Rim15 and Sch9 kinases are involved in induction of autophagic degradation of ribosomes in budding yeast

Autophagic degradation of ribosomes is promoted by nutrient starvation and inactivation of target of rapamycin complex 1 (TORC1). Here we show that selective autophagic degradation of ribosomes (called ribophagy) after TORC1 inactivation requires the specific autophagy receptor Atg11. Rim15 protein...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2017-02, Vol.81 (2), p.307-310
Main Authors: Waliullah, Talukdar Muhammad, Yeasmin, Akter MST, Kaneko, Atsuki, Koike, Naoki, Terasawa, Mashu, Totsuka, Takaya, Ushimaru, Takashi
Format: Article
Language:English
Subjects:
Autophagy
Autophagy-Related Proteins - metabolism
Protein Kinases - metabolism
ribophagy
Ribosomes - metabolism
Rim15
Saccharomyces cerevisiae
Saccharomyces cerevisiae - cytology
Saccharomyces cerevisiae - enzymology
Saccharomyces cerevisiae - metabolism
Saccharomyces cerevisiae Proteins - metabolism
target of rapamycin complex 1 (TORC1)
Vesicular Transport Proteins - metabolism
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Summary:Autophagic degradation of ribosomes is promoted by nutrient starvation and inactivation of target of rapamycin complex 1 (TORC1). Here we show that selective autophagic degradation of ribosomes (called ribophagy) after TORC1 inactivation requires the specific autophagy receptor Atg11. Rim15 protein kinase upregulated ribophagy, while it downregulated non-selective degradation of ribosomes.
ISSN:0916-8451
1347-6947
DOI:10.1080/09168451.2016.1234928