Clinical factors that affect the outcomes after anatomical versus non-anatomical resection for hepatocellular carcinoma

Purpose For hepatocellular carcinoma (HCC), the superiority of anatomical resection (AR) over non-anatomical resection (NR) is still controversial. In this study, we assessed the potential benefits of AR for HCC. Methods We enrolled 173 consecutive patients with HCC who underwent hepatectomy in our...

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Bibliographic Details
Published in:Surgery today (Tokyo, Japan) Japan), 2017-02, Vol.47 (2), p.193-201
Main Authors: Yamamoto, Takehito, Yagi, Shintaro, Uryuhara, Kenji, Kaihara, Satoshi, Hosotani, Ryo
Format: Article
Language:English
Subjects:
Aged
alpha-Fetoproteins - analysis
Bilirubin - blood
Biomarkers, Tumor - blood
Carcinoma, Hepatocellular - mortality
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
Disease-Free Survival
Female
Hepacivirus
Hepatectomy - methods
Hepatectomy - mortality
Humans
Liver Neoplasms - mortality
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Male
Medicine
Medicine & Public Health
Middle Aged
Original Article
Patient Selection
Surgery
Surgical Oncology
Treatment Outcome
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Summary:Purpose For hepatocellular carcinoma (HCC), the superiority of anatomical resection (AR) over non-anatomical resection (NR) is still controversial. In this study, we assessed the potential benefits of AR for HCC. Methods We enrolled 173 consecutive patients with HCC who underwent hepatectomy in our hospital from August 2003 to May 2013 and compared the outcomes for the AR group ( n  = 125) with those for the NR group ( n  = 48). Results The median observational period was 790 days. The 1- and 2-year overall survival (OS) rates were 92.1 and 85.8 %, respectively; the 1- and 2-year disease-free survival (DFS) rates were 78.2 and 63.0 %, respectively. The AR and NR groups did not significantly differ in the OS or DFS. However, the 2-year DFS was significantly better for the AR group than the NR group among HCV patients (68.2 vs. 32.2 %; P  = 0.004) and patients with alpha-fetoprotein (AFP) within the normal range (
ISSN:0941-1291
1436-2813
DOI:10.1007/s00595-016-1397-2