Host–pathogen interactions promoting inflammatory Lyme arthritis: use of mouse models for dissection of disease processes

Recent studies have confirmed the infectious and inflammatory nature of arthritis induced by Borrelia burgdorferi, or Lyme arthritis. This arthritis is directed by the presence of the bacteria in joint tissue, and is mediated through activation of the Toll-like receptor 2 (TLR2) signaling pathways b...

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Bibliographic Details
Published in:Current Opinion in Microbiology 2001-06, Vol.4 (3), p.274-279
Main Authors: Wooten, R.Mark, Weis, Janis J
Format: Article
Language:English
Subjects:
Animals
arthritis
Arthritis, Infectious - etiology
Arthritis, Infectious - immunology
Arthritis, Infectious - microbiology
Borrelia burgdorferi
Borrelia burgdorferi Group - immunology
cytokines
Disease Models, Animal
endothelial cells
inflammation
knockout mice
Lipoproteins - immunology
Lyme disease
Lyme Disease - immunology
Lyme Disease - physiopathology
macrophages
Mice
mouse model
TLR2
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Summary:Recent studies have confirmed the infectious and inflammatory nature of arthritis induced by Borrelia burgdorferi, or Lyme arthritis. This arthritis is directed by the presence of the bacteria in joint tissue, and is mediated through activation of the Toll-like receptor 2 (TLR2) signaling pathways by borrelial lipoproteins. Several host genes regulate the severity of arthritis, possibly by regulating the balance of pro- and anti-inflammatory responses.
ISSN:1369-5274
1879-0364
DOI:10.1016/S1369-5274(00)00202-2