A visible-light-induced chemoselective radical/oxidative addition domino process to access α-chloro and α-alkoxy aryl ketones

A visible-light-induced radical-triggered chemoselective domino process to access α,α-di-functionalized ketones under mild conditions has been developed. This protocol provides a direct approach to synthesize α-chloro or α-alkoxy aryl ketones based on the electronic properties of the substrates. The...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2016-01, Vol.52 (89), p.13105-13108
Main Authors: Niu, Teng-Fei, Jiang, Ding-Yun, Li, Si-Yuan, Ni, Bang-Qing, Wang, Liang
Format: Article
Language:English
Subjects:
Aromatic compounds
Electronic properties
Functional groups
Ketones
Radicals
Substrates
Synthesis
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Summary:A visible-light-induced radical-triggered chemoselective domino process to access α,α-di-functionalized ketones under mild conditions has been developed. This protocol provides a direct approach to synthesize α-chloro or α-alkoxy aryl ketones based on the electronic properties of the substrates. The reaction can tolerate a variety of functional groups to afford the corresponding products in moderate to good yields.
ISSN:1359-7345
1364-548X
DOI:10.1039/c6cc07272k