Fish scale derived hydroxyapatite scaffold for bone tissue engineering

The tailored mechanical characteristics of bioceramic scaffold are very important for the bone tissue engineering. Functional hydroxyapatite (HAp) synthesized from fish scale (Labio rohita &Catla catla) is explored as scaffold materials. HAp scaffold exhibits better mechanical properties such as...

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Bibliographic Details
Published in:Materials characterization 2016-11, Vol.121, p.112-124
Main Authors: Mondal, B, Mondal, S., Mondal, A., Mandal, N.
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
Bones
Cell-attachment
Cytotoxicity
Flakes (defects)
Hydroxyapatite
Mechanical properties
Scaffold
Scaffolds
Sintering
Surgical implants
Tissue- engineering
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Summary:The tailored mechanical characteristics of bioceramic scaffold are very important for the bone tissue engineering. Functional hydroxyapatite (HAp) synthesized from fish scale (Labio rohita &Catla catla) is explored as scaffold materials. HAp scaffold exhibits better mechanical properties such as hardness (~1.08GPa), compressive strength (~0.8GPa) and tensile strength (~187MPa) with adequate porosity (~35%) compared to commercial and synthetic body fluid derived HAp. The in vitro assays (MTT, LDH and Trypan blue) with MG63 osteoblast cell lines reveal that fish scale derived HAp materials is non-toxic and bioactive. The in vivo histological analysis of implanted HAp scaffold shows the osteo-conductive characteristics. The findings are significant with respect to cytotoxicity, osteo-conductivity and mechanical stability during bio-mineralization of traumatized bone tissues. [Display omitted] •HAp scaffold exhibits better compressive (~0.8GPa) and tensile strength (~187MPa).•HAp scaffold shows the osteo-conductive characteristics.•Fish scale derived HAp materials is non-toxic and bioactive with MG63 osteoblast cell lines.
ISSN:1044-5803
1873-4189
DOI:10.1016/j.matchar.2016.09.034