Dengue tropism for macrophages and dendritic cells: the host cell effect

Dengue virus infects immune cells, including monocytes, macrophages and dendritic cells (DC). We compared virus infectivity in macrophages and DC, and found that the virus origin determined the cell tropism of progeny virus. The highest efficiency of re-infection was seen for macrophage-derived deng...

Full description

Saved in:

Bibliographic Details
Published in:	Journal of general virology 2016-07, Vol.97 (7), p.1531-1536
Main Authors:	Flipse, Jacky, Torres, Silvia, Diosa-Toro, Mayra, van der Ende-Metselaar, Heidi, Herrera-Rodriguez, José, Urcuqui-Inchima, Silvio, Huckriede, Anke, Rodenhuis-Zybert, Izabela A, Smit, Jolanda M
Format:	Article
Language:	eng
Subjects:	Cells, Cultured Dendritic Cells - virology Dengue - transmission Dengue - virology Dengue Virus - growth & development Dengue Virus - pathogenicity Flaviviridae Humans Macrophages - virology Virus Replication - physiology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Dengue virus infects immune cells, including monocytes, macrophages and dendritic cells (DC). We compared virus infectivity in macrophages and DC, and found that the virus origin determined the cell tropism of progeny virus. The highest efficiency of re-infection was seen for macrophage-derived dengue virus. Furthermore, in the presence of enhancing antibodies, macrophage-derived virus gave greater enhancement of infection compared with immature DC-derived virus. Taken together, our results highlight the importance of macrophages in dengue infection.
ISSN:	0022-1317 1465-2099