Activated and expanded natural killer cells target osteosarcoma tumor initiating cells in an NKG2D–NKG2DL dependent manner

Highlights • NK cells ability to target osteosarcoma cells and the pathways involved were studied. • We explored NK cell elimination of osteosarcoma (OS) Tumor Initiating Cells (TICs). • NKG2D–NKG2DL pathway is involved in NK cell elimination of OS cells, including TICs. • NK cells reduce tumor volu...

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Bibliographic Details
Published in:Cancer letters 2015-11, Vol.368 (1), p.54-63
Main Authors: Fernández, L, Valentín, J, Zalacain, M, Leung, W, Patiño-García, A, Pérez-Martínez, A
Format: Article
Language:English
Subjects:
Animals
Antigens
Antineoplastic Agents - pharmacology
Bone cancer
Bone Neoplasms - immunology
Bone Neoplasms - metabolism
Bone Neoplasms - pathology
Bone Neoplasms - therapy
Cancer therapies
Cell Communication
Cell Line, Tumor
Cell Proliferation
Chemoresistance
Chemotherapy
Cloning
Coculture Techniques
Colleges & universities
Cytolytic activity
Cytotoxicity
Cytotoxicity, Immunologic
Flow cytometry
Hematology, Oncology and Palliative Medicine
Humans
Immunotherapy
Immunotherapy, Adoptive - methods
Killer Cells, Lymphokine-Activated - immunology
Killer Cells, Lymphokine-Activated - metabolism
Killer Cells, Lymphokine-Activated - transplantation
Ligands
Lymphocyte Activation
Lysis
Medical prognosis
Metastases
Metastasis
Mice, Inbred NOD
Mice, SCID
Natural killer cells
Neoplastic Stem Cells - drug effects
Neoplastic Stem Cells - immunology
Neoplastic Stem Cells - metabolism
Neoplastic Stem Cells - pathology
NK Cell Lectin-Like Receptor Subfamily K - immunology
NK Cell Lectin-Like Receptor Subfamily K - metabolism
NKG2 antigen
NKG2D–NKG2DL interactions
Osteosarcoma
Osteosarcoma - immunology
Osteosarcoma - metabolism
Osteosarcoma - pathology
Osteosarcoma - therapy
Osteosarcoma tumor initiating cells
Sarcoma
Signal Transduction
Spironolactone - pharmacology
Stem cells
Time Factors
Young adults
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Summary:Highlights • NK cells ability to target osteosarcoma cells and the pathways involved were studied. • We explored NK cell elimination of osteosarcoma (OS) Tumor Initiating Cells (TICs). • NKG2D–NKG2DL pathway is involved in NK cell elimination of OS cells, including TICs. • NK cells reduce tumor volume, metastasis and improve survival in an OS animal model.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2015.07.042