Investigation of Apparent Diffusion Coefficient from Ultra-high b-Values in Parkinson’s Disease

Objectives To assess brain damage in Parkinson’s disease (PD) based on apparent diffusion coefficient (ADC) data obtained from ultra-high b-values. Methods Eighteen PD patients and 18 controls received diffusion-weighted imaging (DWI) with standard b-values (0, 1,000 s/mm 2 ) and 15 b-values (0–5,00...

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Bibliographic Details
Published in:European radiology 2015-09, Vol.25 (9), p.2593-2600
Main Authors: Xueying, Ling, Zhongping, Zhang, Zhoushe, Zhao, Li, Guo, Yongjin, Tang, Changzheng, Shi, Zhifeng, Zhou, Peihao, Chen, Hao, Xu, Li, Huang
Format: Article
Language:English
Subjects:
Adult
Aged
Brain - pathology
Brain cancer
Brain damage
Brain Mapping - methods
Diabetes
Diagnostic Radiology
Diffusion Magnetic Resonance Imaging - methods
Disease
Female
Hospitals
Humans
Imaging
Internal Medicine
Interventional Radiology
Male
Medicine
Medicine & Public Health
Middle Aged
Neuro
Neuroradiology
Parkinson Disease - pathology
Parkinson's disease
Permeability
Prospective Studies
Radiology
Tissues
Ultrasound
Water transportation
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Summary:Objectives To assess brain damage in Parkinson’s disease (PD) based on apparent diffusion coefficient (ADC) data obtained from ultra-high b-values. Methods Eighteen PD patients and 18 controls received diffusion-weighted imaging (DWI) with standard b-values (0, 1,000 s/mm 2 ) and 15 b-values (0–5,000 s/mm 2 ). Standard ADC (ADC st ) maps were calculated from standard b-values, while maps of pure diffusion coefficients (D), pseudo-diffusion coefficients (D * ), and ultra-high ADCs (ADC uh ) were calculated from the 15 b-values using a tri-component model. In this model, D and D * values were quantified with a bi-exponential equation using b-values less than 2,000 s/mm 2 , while ADC uh was quantified by fitting the signals at ultra-high b-values (2,000–5,000 s/mm 2 ) to the mono-exponential equation. ADC st , ADC uh , D, and D * of the globus pallidus (GP), putamen (P), and substantia nigra (SN) were compared between PD patients and normal control subjects. Results ADC uh of the GP, P, and SN was significantly lower in PD patients than those in control subjects ( P   0.05). Conclusions ADC uh may be a useful measurement for evaluating brain damage in PD patients. Key Points • DWI with ultra - high b - values may provide new insight into Parkinson ’ s disease pathology • ADC calculated using ultra - high b - values is different between PD and controls • ADC uh may be associated with water transportation by aquaporins
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-015-3678-3