Abnormal distribution of GABAA receptors in brain of duchenne muscular dystrophy patients

ABSTRACT Introduction: In this study we sought to: (1) determine the distribution of GABAA receptors (GABAA‐Rs) in the brain of Duchenne muscular dystrophy (DMD) patients; and (2) ascertain if the distribution pattern correlates with cognitive dysfunction. Methods: Fourteen DMD patients [young adult...

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Bibliographic Details
Published in:Muscle & nerve 2017-04, Vol.55 (4), p.591-595
Main Authors: Suzuki, Yuji, Higuchi, Shinya, Aida, Izumi, Nakajima, Takashi, Nakada, Tsutomu
Format: Article
Language:English
Subjects:
123I‐iomazenil‐SPECT
brain
cognitive dysfunction
Duchenne muscular dystrophy
GABAA receptor
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Summary:ABSTRACT Introduction: In this study we sought to: (1) determine the distribution of GABAA receptors (GABAA‐Rs) in the brain of Duchenne muscular dystrophy (DMD) patients; and (2) ascertain if the distribution pattern correlates with cognitive dysfunction. Methods: Fourteen DMD patients [young adult (n = 7, 18–25 years old) and older adult (n = 7, 30–37 years old) groups] and 16 age‐matched normal volunteers participated. GABAA‐R distribution was assessed using 123I‐IMZ‐SPECT. Neuropsychological assessments were performed using 3 different test batteries, the WAIS‐III, WMS‐R, and Wisconsin Card Sorting Test (WCST). Results: All DMD patients showed significant decline in 123I‐IMZ uptake in the prefrontal cortex (P 
ISSN:0148-639X
1097-4598
DOI:10.1002/mus.25383