L1 retrotransposition alters the hippocampal genomic landscape enabling memory formation

Highlights • De novo L1 insertions occur in the adult hippocampus after exploration. • Blocking hippocampal L1 retrotransposition events prevents long-term memory formation. • Hippocampal L1 activity enables for long-term memory consolidation.

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2017-08, Vol.64, p.65-70
Main Authors: Bachiller, Sara, del-Pozo-Martín, Yaiza, Manuel Carrión, Ángel
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Gene expression
Genomics
Hippocampus
Hippocampus - metabolism
LINE1
Long Interspersed Nucleotide Elements
Male
Memory formation
Memory, Long-Term
Mice
Mosaicism
Psychiatry
Retroelements
Retrotransposition
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Description
Summary:Highlights • De novo L1 insertions occur in the adult hippocampus after exploration. • Blocking hippocampal L1 retrotransposition events prevents long-term memory formation. • Hippocampal L1 activity enables for long-term memory consolidation.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2016.12.018