Concordance of 18F-FDG PET Uptake in Tumor and Normal Tissues on PET/MRI and PET/CT

AIMThe aim of this study was to assess the concordance of PET measurements of F-FDG uptake in tumor and normal tissues obtained on Australia’s first clinical PET/MRI scanner in comparison to PET/CT, with comparison against published data. METHODSOne hundred subjects were prospectively recruited from...

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Bibliographic Details
Published in:Clinical nuclear medicine 2017-03, Vol.42 (3), p.180-186
Main Authors: Law, W Phillip, Maggacis, Nicole, Jeavons, Susanne J, Miles, Kenneth A
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Female
Fluorodeoxyglucose F18 - pharmacokinetics
Humans
Image Processing, Computer-Assisted
Liver - diagnostic imaging
Liver - metabolism
Magnetic Resonance Imaging
Male
Mediastinum - diagnostic imaging
Middle Aged
Multimodal Imaging
Neoplasms - diagnostic imaging
Neoplasms - metabolism
Positron Emission Tomography Computed Tomography
Positron-Emission Tomography
Prospective Studies
Radiopharmaceuticals - metabolism
Young Adult
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Summary:AIMThe aim of this study was to assess the concordance of PET measurements of F-FDG uptake in tumor and normal tissues obtained on Australia’s first clinical PET/MRI scanner in comparison to PET/CT, with comparison against published data. METHODSOne hundred subjects were prospectively recruited from an unselected, heterogeneous group of cancer patients to undergo F-FDG PET/CT and PET/MRI on the same day. SUVs of physiological regions and tumor tissues obtained by PET/MRI and PET/CT were compared and benchmarked against existing published data. Physiological activity was measured in the thoracic aorta and right lobe of the liver. Tumor SUVs were analyzed by cancer type, body region, and a combined group of all lesions. RESULTSThere was an excellent correlation between SUV measurements in tumor lesions obtained by PET/MRI and PET/CT, across all body regions and in all tumor types studied. There was a less robust correlation for SUVs measured in areas of physiological activity, but the level of agreement still fell within 2 SDs of mean. Data from this study showed comparable or smaller systemic biases and narrower confidence limits than existing studies in the literature comparing SUVs from PET/MRI and PET/CT. CONCLUSIONSF-FDG PET/MRI appears promising as an adjunct or alternative to PET/CT for quantitative evaluation in oncology, independent of body region and tumor type, across a wide range of SUVs.
ISSN:0363-9762
1536-0229
DOI:10.1097/RLU.0000000000001514