Tumor B7-H3 (CD276) expression and smoking history in relation to lung adenocarcinoma prognosis

Highlights • We evaluated tumor B7-H3 expression by IHC in 270 lung adenocarcinomas. • We demonstrated a significant prognostic interaction of B7-H3 with smoking history. • In smoking patients, high B7-H3 expression was associated with decreased survival. • In non-smoking patients, high B7-H3 expres...

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Bibliographic Details
Published in:Lung cancer (Amsterdam, Netherlands) Netherlands), 2017-01, Vol.103, p.44-51
Main Authors: Inamura, Kentaro, Yokouchi, Yusuke, Kobayashi, Maki, Sakakibara, Rie, Ninomiya, Hironori, Subat, Sophia, Nagano, Hiroko, Nomura, Kimie, Okumura, Sakae, Shibutani, Tomoko, Ishikawa, Yuichi
Format: Article
Language:English
Subjects:
B7-H3
Hematology, Oncology and Palliative Medicine
Immune checkpoint
Immunotherapy
Lung cancer
Prognostic interaction
Pulmonary/Respiratory
Smoking
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Summary:Highlights • We evaluated tumor B7-H3 expression by IHC in 270 lung adenocarcinomas. • We demonstrated a significant prognostic interaction of B7-H3 with smoking history. • In smoking patients, high B7-H3 expression was associated with decreased survival. • In non-smoking patients, high B7-H3 expression was not associated with survival. • High B7-H3 expression was associated with EGFR wild-type and smoking patients.
ISSN:0169-5002
1872-8332
DOI:10.1016/j.lungcan.2016.11.013