Reduced allergic lung inflammation by root extracts from two species of Peucedanum through inhibition of Th2 cell activation

Peucedani Radix (PR), the root of Peucedanum praeruptorum Dunn (PPD) or Peucedanum decursivum (Miq.) Maxim. (PDM), has long been used in Korea to eliminate sputum, relieve cough, and reduce bronchus contraction. Furthermore, these therapeutic strategies are recognized as general and effective method...

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Bibliographic Details
Published in:Journal of ethnopharmacology 2017-01, Vol.196, p.75-83
Main Authors: Lee, A.-Reum, Chun, Jin Mi, Lee, A. Yeong, Kim, Hyo Seon, Gu, Gyo Jeong, Kwon, Bo-In
Format: Article
Language:English
Subjects:
Allergens - immunology
Allergic lung inflammation
Animals
Anti-Asthmatic Agents - pharmacology
Anti-Asthmatic Agents - therapeutic use
Apiaceae
Asthma - drug therapy
Asthma - immunology
Asthma - pathology
Bronchoalveolar Lavage Fluid - chemistry
Bronchoalveolar Lavage Fluid - cytology
Bronchoalveolar Lavage Fluid - immunology
CD4-Positive T-Lymphocytes - drug effects
CD4-Positive T-Lymphocytes - immunology
Cell Count
Cytokines - immunology
Eosinophilia - drug therapy
Eosinophilia - immunology
Eosinophilia - pathology
Female
GATA3 Transcription Factor - immunology
Histamine
Histamine - immunology
Immunoglobulin E - blood
Lung - drug effects
Lung - immunology
Lung - pathology
Mice, Inbred C57BL
Mucus - metabolism
Ovalbumin - immunology
Peucedanum decursivum (Miq.) Maxim (PDM)
Peucedanum praeruptorum Dunn (PPD)
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Roots
Th2 cell activation
Type2 cytokines
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Summary:Peucedani Radix (PR), the root of Peucedanum praeruptorum Dunn (PPD) or Peucedanum decursivum (Miq.) Maxim. (PDM), has long been used in Korea to eliminate sputum, relieve cough, and reduce bronchus contraction. Furthermore, these therapeutic strategies are recognized as general and effective methods in western medicine as well as traditional Korean medicine. To determine and compare the anti-inflammatory effects of PPD extracts (PPDE) and PDM extracts (PDME) on allergic lung inflammation, using in vivo OVA-induced airway inflammation in mice and in vitro primary cell culture systems. Eight-week-old female C57BL/6 mice were placed into four groups (n=4 per group): saline control, OVA-induced allergic lung inflammation with vehicle, or PPDE (200mg/kg) or PDME (200mg/kg) treatment. PR extracts (PRE) were administered from 1 week before 1st OVA sensitization to the day before sacrifice. Mice were sacrificed 18h after last OVA intra-nasal challenge followed by histological and biochemical analyses. Inflammatory phenotypes were alleviated with oral administration of PRE. PRE treatment decreased mucus production in airway epithelium, inflammatory cell number, eosinophilia, type 2 cytokines, and histamine in bronchoalveolar lavage fluid (BALF). Mice with PRE administration showed diminished activated CD4 T cell (CD4+CD25+ cell) and GATA-3 level in the lung. In addition, PRE treatment reduced Th2 cell activation in vitro, using Th2 polarization system. Our findings indicate that the anti-inflammatory effects of PRE arise from reduced Th2 cell activation and validate the clinical use of PR in traditional Korean medicine. [Display omitted]
ISSN:0378-8741
1872-7573
DOI:10.1016/j.jep.2016.12.015