The Use of Systemic and Topical Fluoroquinolones

Appropriate prescribing practices for fluoroquinolones, as well as all antimicrobial agents, are essential as evolving resistance patterns are considered, additional treatment indications are identified, and the toxicity profile of fluoroquinolones in children has become better defined. Earlier reco...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2016-11, Vol.138 (5), p.e1
Main Authors: Jackson, Mary Anne, Schutze, Gordon E
Format: Article
Language:English
Subjects:
Administration, Oral
Administration, Topical
Age Factors
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - adverse effects
Antimicrobial agents
Bacterial Infections - drug therapy
Bacterial Infections - microbiology
Child
Child, Preschool
Children & youth
Drug Resistance, Microbial
Drug Utilization - statistics & numerical data
Female
Fluoroquinolones - administration & dosage
Fluoroquinolones - adverse effects
Humans
Male
Medical treatment
Patient Safety
Pediatrics
Prescription drugs
Risk Assessment
Toxicity
Treatment Outcome
United States
United States Food and Drug Administration
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Summary:Appropriate prescribing practices for fluoroquinolones, as well as all antimicrobial agents, are essential as evolving resistance patterns are considered, additional treatment indications are identified, and the toxicity profile of fluoroquinolones in children has become better defined. Earlier recommendations for systemic therapy remain; expanded uses of fluoroquinolones for the treatment of certain infections are outlined in this report. Prescribing clinicians should be aware of specific adverse reactions associated with fluoroquinolones, and their use in children should continue to be limited to the treatment of infections for which no safe and effective alternative exists or in situations in which oral fluoroquinolone treatment represents a reasonable alternative to parenteral antimicrobial therapy.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2016-2706