Platelet count is associated with cardiovascular disease, cancer and mortality: A population-based cohort study

Abstract Introduction Platelet count is used to determine bleeding risk and monitoring thrombopoiesis. While abnormal platelet counts are associated with mortality and morbidity, it is unclear whether it also apply to platelet counts within reference range. We investigated the relationship between p...

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Published in:Thrombosis research 2016-12, Vol.148, p.136-142
Main Authors: Vinholt, P.J, Hvas, A.M, Frederiksen, H, Bathum, L, Jørgensen, M.K, Nybo, M
Format: Article
Language:English
Subjects:
Adult
Aged
Cardiovascular diseases
Cardiovascular Diseases - diagnosis
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - mortality
Cohort Studies
Denmark - epidemiology
Female
Hematology, Oncology and Palliative Medicine
Humans
Male
Middle Aged
Mortality
Neoplasms
Neoplasms - diagnosis
Neoplasms - epidemiology
Neoplasms - mortality
Platelet Count
Prognosis
Proportional Hazards Models
Risk Factors
Thrombocytopenia
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Summary:Abstract Introduction Platelet count is used to determine bleeding risk and monitoring thrombopoiesis. While abnormal platelet counts are associated with mortality and morbidity, it is unclear whether it also apply to platelet counts within reference range. We investigated the relationship between platelet count (100 – 450 × 109 /L) and mortality, development of future cardiovascular disease (myocardial infarction, ischaemic stroke, or peripheral vascular disease), venous thromboembolism, bleeding or cancer in the general population. Material and methods We conducted a register-based cohort study of 21,252 adults (≥ 20 years) from the Danish General Suburban Population Study (GESUS). Laboratory results from GESUS were linked to information from national registers regarding morbidity and death. Cox proportional hazard regression was conducted with adjustment for age, sex, smoking status, haemoglobin, leukocyte count, C-reactive protein and Charlson comorbidity index. Results We found a U-shaped relationship between mortality and platelet count. Mortality was significantly increased for platelet count < 175 × 109 /L or > 300 × 109 /L. When categorizing platelet count using the interval 201 – 250 × 109 /L as reference group, platelet count 301 – 450 × 109 /L was associated with mortality, adjusted hazard ratio (HR) = 1.42(95% CI 1.06 – 1.90) and cardiovascular disease, adjusted HR = 1.32 (95% CI 1.03 – 1.69). Platelet count 100 – 200 × 109 /L was associated with future cancer, adjusted HR = 1.28(95% CI 1.05 – 1.57), but not with future bleeding or venous thromboembolism. Conclusions Platelet count is associated with mortality, future cardiovascular disease, and future cancer.
ISSN:0049-3848
1879-2472
DOI:10.1016/j.thromres.2016.08.012