Cyanobacterial metabolic engineering for biofuel and chemical production

•Metabolic engineering of cyanobacteria for biofuel and bulk chemical production.•Photoheterotrophic production is improving titers in light and dark conditions.•Terpenoid biosynthesis is expanding range of biofuels from cyanobacteria.•Biodegradable plastic feedstocks and carbohydrate production are...

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Bibliographic Details
Published in:Current opinion in chemical biology 2016-12, Vol.35, p.43-50
Main Authors: Oliver, Neal J, Rabinovitch-Deere, Christine A, Carroll, Austin L, Nozzi, Nicole E, Case, Anna E, Atsumi, Shota
Format: Article
Language:English
Subjects:
Alcohols - metabolism
Biofuels
Carbohydrate Metabolism
Carboxylic Acids - metabolism
Cyanobacteria - metabolism
Hydrocarbons - metabolism
Metabolic Engineering
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Summary:•Metabolic engineering of cyanobacteria for biofuel and bulk chemical production.•Photoheterotrophic production is improving titers in light and dark conditions.•Terpenoid biosynthesis is expanding range of biofuels from cyanobacteria.•Biodegradable plastic feedstocks and carbohydrate production are valuable and promising atmospheric carbon sinks. Rising levels of atmospheric CO2 are contributing to the global greenhouse effect. Large scale use of atmospheric CO2 may be a sustainable and renewable means of chemical and liquid fuel production to mitigate global climate change. Photosynthetic organisms are an ideal platform for efficient, natural CO2 conversion to a broad range of chemicals. Cyanobacteria are especially attractive for these purposes, due to their genetic malleability and relatively fast growth rate. Recent years have yielded a range of work in the metabolic engineering of cyanobacteria and have led to greater knowledge of the host metabolism. Understanding of endogenous and heterologous carbon regulation mechanisms leads to the expansion of productive capacity and chemical variety. This review discusses the recent progress in metabolic engineering of cyanobacteria for biofuel and bulk chemical production since 2014.
ISSN:1367-5931
1879-0402
DOI:10.1016/j.cbpa.2016.08.023