Propofol postconditioning attenuates hippocampus ischemia-reperfusion injury via modulating JAK2/STAT3 pathway in rats after autogenous orthotropic liver transplantation

Highlights • The specific mechanisms of brain injury associated with liver transplantation are not yet elucidated. • Autogenous orthotropic liver autotransplantation causes hippocampus damage as a remote organ. • Propofol attenuates hippocampal ischemia-reperfusion injury via modulating JAK2/STAT3 p...

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Bibliographic Details
Published in:Brain research 2017-02, Vol.1657, p.202-207
Main Authors: Lili, Jia, Fei, Wang, Xiangqian, Gu, Yiqi, Weng, Mingwei, Sheng, Gang, Wang, Shipeng, Li, Hongyin, Du, Wenli, Yu
Format: Article
Language:English
Subjects:
Animals
Apoptosis - drug effects
Apoptosis - physiology
Brain Ischemia - drug therapy
Brain Ischemia - enzymology
Brain Ischemia - etiology
Brain Ischemia - pathology
Hippocampus
Hippocampus - drug effects
Hippocampus - enzymology
Hippocampus - immunology
Hippocampus - pathology
JAK/STAT
Janus Kinase 2 - metabolism
Liver transplantation
Liver Transplantation - adverse effects
Male
Neurology
Neuroprotective Agents - pharmacology
Nitric Oxide - metabolism
Nitric Oxide Synthase Type II - metabolism
Propofol
Propofol - pharmacology
Random Allocation
Rats, Sprague-Dawley
Reperfusion Injury - drug therapy
Reperfusion Injury - enzymology
Reperfusion Injury - etiology
Reperfusion Injury - pathology
RNA, Messenger - metabolism
Signal Transduction - drug effects
STAT3 Transcription Factor - metabolism
Transplantation, Autologous - adverse effects
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Summary:Highlights • The specific mechanisms of brain injury associated with liver transplantation are not yet elucidated. • Autogenous orthotropic liver autotransplantation causes hippocampus damage as a remote organ. • Propofol attenuates hippocampal ischemia-reperfusion injury via modulating JAK2/STAT3 pathway.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2016.12.015