Trypanocidal activity of the compounds present in Aniba canelilla oil against Trypanosoma evansi and its effects on viability of lymphocytes

Aniba canelilla (H.B.K.) Mez, popularly known as “casca-preciosa” (precious bark), is a plant of the Lauraceae family, widely distributed in the Amazon region. Its major constituent is 1-nitro-2-phenylethane, a rare molecule in plants which is responsible for this plant's cinnamon scent. The pr...

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Bibliographic Details
Published in:Microbial pathogenesis 2017-02, Vol.103, p.13-18
Main Authors: Giongo, Janice L., Vaucher, Rodrigo A., Da Silva, Aleksandro S., Oliveira, Camila B., de Mattos, Cristiane B., Baldissera, Matheus D., Sagrillo, Michele R., Monteiro, Silvia G., Custódio, Dayana L., Souza de Matos, Marcielly, Sampaio, Paulo T., Teixeira, Helder F., Koester, Letícia S., da Veiga Junior, Valdir F.
Format: Article
Language:English
Subjects:
1-Nitro-2-phenylethane
Aniba canelilla
Antiprotozoal activity
Cell Survival - drug effects
Chromatography, Gas
Embryophyta - chemistry
Essential oil composition
Humans
Lymphocytes - drug effects
Methyleugenol
Oils, Volatile - chemistry
Oils, Volatile - pharmacology
Plant Extracts - chemistry
Plant Extracts - pharmacology
Plant Oils - chemistry
Plant Oils - pharmacology
Trypanocidal Agents - chemistry
Trypanocidal Agents - pharmacology
Trypanosoma - drug effects
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Summary:Aniba canelilla (H.B.K.) Mez, popularly known as “casca-preciosa” (precious bark), is a plant of the Lauraceae family, widely distributed in the Amazon region. Its major constituent is 1-nitro-2-phenylethane, a rare molecule in plants which is responsible for this plant's cinnamon scent. The present study aimed to report the chemical characterization of the oil extracted from Aniba canelilla using gas-chromatography/mass spectrometry and to assess its in vitro trypanocidal activity against Trypanosoma evansi, a prevalent haemoflagellate parasite that affects a broad range of mammal species in Africa, Asia and South America. The oil presented 1-nitro-2-phenylethane (83.68%) and methyleugenol (14.83%) as the two major components. The essential oil as well as both major compounds were shown to exert trypanocidal effect. Methyleugenol was slightly more active than 1-nitro-2-phenylethane. In vitro studies showed that the oil extracted from the stems of A. canelilla may be regarded as a potential natural treatment for trypanosomosis, once proven their in vivo action, may be an interesting alternative in the treatment of infected animals with T. evansi. [Display omitted] •Aniba canelilla essential oil has in vitro trypanocidal action against Trypanosoma evansi.•Methyleugenol and 1-nitro-2-phenylethane, isolated or associated, has in vitro trypanocidal action.•These compounds may be considered responsible for the in vitro trypanocidal action.•A. canelilla may be considered an important approach to treat infected animals by T. evansi.
ISSN:0882-4010
1096-1208
DOI:10.1016/j.micpath.2016.12.006