Perinatal Brain Injury is Accompanied by Disturbances in Expression of SLC Protein Superfamily in Endotheliocytes of Hippocampal Microvessels

The peculiarities in expression of transport proteins and the proteins implicated in the control of glycolysis by the cellular components of neurovascular units were examined in animals of different age under normal conditions and after modeled perinatal stress or hypoxic brain injury. In both cases...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-10, Vol.161 (6), p.770-774
Main Authors: Morgun, A. V., Kuvacheva, N. V., Khilazheva, E. D., Pozhilenkova, E. A., Gorina, Ya. V., Malinovskaya, N. A., Komleva, Yu. K., Lopatina, O. L., Panina, Yu. A., Gasymly, E. D., Salmina, A. B.
Format: Article
Language:English
Subjects:
Age Factors
Analysis
Animals
Animals, Newborn
Anxiety, Separation - complications
Anxiety, Separation - genetics
Anxiety, Separation - metabolism
Anxiety, Separation - pathology
Astrocytes - metabolism
Astrocytes - pathology
Biomedical and Life Sciences
Biomedicine
Biophysics and Biochemistry
Blood-Brain Barrier - metabolism
Blood-Brain Barrier - pathology
Brain
Brain injuries
Cell Biology
Endothelial Cells - metabolism
Endothelial Cells - pathology
Female
Gene Expression Regulation
Glucose metabolism
Glucose Transporter Type 4 - genetics
Glucose Transporter Type 4 - metabolism
Glutamate
Glycogen Synthase Kinase 3 - genetics
Glycogen Synthase Kinase 3 - metabolism
Hippocampus - blood supply
Hippocampus - metabolism
Hippocampus - pathology
Humans
Hypoxia - complications
Hypoxia - genetics
Hypoxia - metabolism
Hypoxia - pathology
Hypoxia-Inducible Factor 1, alpha Subunit - genetics
Hypoxia-Inducible Factor 1, alpha Subunit - metabolism
Internal Medicine
Laboratory Medicine
Male
Metabolites
Microvessels - metabolism
Microvessels - pathology
Neurons
Neurons - metabolism
Neurons - pathology
Neurovascular Coupling
Pathology
Rats
Rats, Wistar
Stress, Psychological - complications
Stress, Psychological - genetics
Stress, Psychological - metabolism
Stress, Psychological - pathology
Transport proteins
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Summary:The peculiarities in expression of transport proteins and the proteins implicated in the control of glycolysis by the cellular components of neurovascular units were examined in animals of different age under normal conditions and after modeled perinatal stress or hypoxic brain injury. In both cases, the specialties in expression of transport proteins in ontogenesis were revealed. The perinatal hypoxic brain injury resulted in up-regulation of MCT1, MCT4, and GLUT4 expression in endotheliocytes of hippocampal microvessels accompanied by transient elevation of HIF-1α and GSK3 expression.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3506-z