Effects of manganese exposure on visuoperception and visual memory in schoolchildren

•Mn and Pb levels were measured.•Assessment of the visuoperception and visual memory in schoolchildren.•MnH and Pb positive association with some visuoperceptual errors.•MnH and Pb positive association with some visual memory errors and total score.•Mn affected the visuoperception and visual memory...

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Published in:Neurotoxicology (Park Forest South) 2016-12, Vol.57, p.230-240
Main Authors: Hernández-Bonilla, D., Escamilla-Núñez, C., Mergler, D., Rodríguez-Dozal, S., Cortez-Lugo, M., Montes, S., Tristán-López, L.A., Catalán-Vázquez, M., Schilmann, A., Riojas-Rodriguez, Horacio
Format: Article
Language:English
Subjects:
Child
Children
Cognition
Cross-Sectional Studies
Elementary school students
Environmental effects
Environmental Exposure
Exposure
Female
Human exposure
Humans
Male
Manganese
Manganese - blood
Manganese - toxicity
Manganese compounds
Memory
Memory, Short-Term - drug effects
Mexico - epidemiology
Mining
Nervous system
Neuropsychological Tests
Neurotoxicity
Psychomotor Performance - drug effects
Recall
Regression analysis
Regression models
Retrospective Studies
Schoolchildren
Socioeconomics
Visual effects
Visual memory
Visual perception
Visual Perception - drug effects
Visuoperception
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Summary:•Mn and Pb levels were measured.•Assessment of the visuoperception and visual memory in schoolchildren.•MnH and Pb positive association with some visuoperceptual errors.•MnH and Pb positive association with some visual memory errors and total score.•Mn affected the visuoperception and visual memory in schoolchildren. Manganese (Mn) is an essential metal involved in multiple physiological functions. Environmental exposure to airborne Mn is associated with neurocognitive deficits in humans. Children, whose nervous system is in development, are particularly susceptible to Mn neurotoxicity. The objective of this study was to assess the association between Mn environmental exposure, and effects on visuoperception and visual memory in schoolchildren. We assessed schoolchildren between 7 and 11 years old, with similar socioeconomic status, from the mining district of Molango (n=148) and Agua Blanca (n=119, non-mining area) in Hidalgo state, Mexico. The Rey-Osterrieth Complex Figure (ROCF) test was used to assess visuoperception and short-term visual memory. Hair manganese (MnH) concentrations were determined. Linear regression models were constructed to estimate the associations between MnH and ROCF scores, adjusted for potential confounders. The geometric mean MnH was nine times higher in schoolchildren from the Mn mining area (5.25μg/g) than in schoolchildren from the non-mining area (0.55μg/g). For the ROCF Copy trial, MnH was significantly associated with an increase in distortion errors (tangency, closure), angle errors, overtracing (partial overtracing). In the Immediate Recall trial, MnH was significantly associated with increased overtracing (partial overtracing) and omissions, and negatively associated with the number of perceptual drawn units, total score and percentage immediate recall. MnH is associated with alterations in visuoperception and short-term visual memory in schoolchildren exposed to airborne Mn.
ISSN:0161-813X
1872-9711
DOI:10.1016/j.neuro.2016.10.006