ASSESSMENT OF T-2 TOXIN EFFECT AND ITS COMBINATION WITH GROWTH FACTOR AND METABOLIC HORMONES ON 17β-ESTRADIOL SECRETION BY RABBIT OVARIAN FRAGMENTS IN VITRO

Assessment of T-2 effect and its combination with growth factor IGF-I, metabolic hormones leptin and ghrelin on 17β-estradiol secretion by rabbit ovarian fragments was studied. Rabbit ovarian fragments were incubated without (control group) or with alone T-2 toxin (0.01; 0.1; 1; 10; and 100 ng.mL-1)...

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Published in:Journal of microbiology, biotechnology and food sciences biotechnology and food sciences, 2015-02, Vol.4 (special issue 2 (Biotechnology)), p.51-53
Main Authors: Kolesárová, Adriana, Maruniaková, Nora, Kádasi, Attila, Packová, Dagmara, Halenár, Marek, V. Sirotkin, Alexander, Bulla, Jozef
Format: Article
Language:English
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Summary:Assessment of T-2 effect and its combination with growth factor IGF-I, metabolic hormones leptin and ghrelin on 17β-estradiol secretion by rabbit ovarian fragments was studied. Rabbit ovarian fragments were incubated without (control group) or with alone T-2 toxin (0.01; 0.1; 1; 10; and 100 ng.mL-1), or its combination with insulin-like growth factor I - IGF-I (100 ng.mL-1), leptin (1000 ng.mL-1) or ghrelin (500 ng.mL-1) for 24 hours. Secretion of 17β-estradiol was determined by ELISA. T-2 toxin was not shown to be potential regulator of 17β-estradiol secretion in rabbit ovarian fragments. On the other hand T-2 toxin at all used doses combined with IGF-I significantly (P
ISSN:1338-5178
1338-5178
DOI:10.15414/jmbfs.2015.4.special2.51-53