Effect of GnRH and hCG on progesterone concentration and ovarian and luteal blood flow in diestrous mares

•The mare is a valuable model for studying the mechanisms regulating ovarian blood flow.•Progesterone does not seem to have a role in acute regulation of ovarian vascular perfusion during diestrus.•LH and hCG might have direct effects on of ovarian vascular perfusion during diestrus.•GnRH effects on...

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Bibliographic Details
Published in:Animal reproduction science 2017-01, Vol.176, p.64-69
Main Authors: Brito, L.F.C., Baldrighi, J.M., Wolf, C.A., Ginther, O.J.
Format: Article
Language:English
Subjects:
Animals
Blood flow
Chorionic Gonadotropin - administration & dosage
Chorionic Gonadotropin - pharmacology
Corpus luteum
Diestrus - blood
Diestrus - drug effects
Diestrus - physiology
Female
GnRH
Gonadotropin-Releasing Hormone - administration & dosage
Gonadotropin-Releasing Hormone - pharmacology
hCG
Horses
Luteinizing Hormone
Ovary
Ovary - blood supply
Ovary - physiology
Progesterone - blood
Progesterone - metabolism
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Summary:•The mare is a valuable model for studying the mechanisms regulating ovarian blood flow.•Progesterone does not seem to have a role in acute regulation of ovarian vascular perfusion during diestrus.•LH and hCG might have direct effects on of ovarian vascular perfusion during diestrus.•GnRH effects on ovarian blood flow might be mediated by LH or by direct effects on ovarian blood vessels. The objective of the present study was to investigate the effect of reproductive hormones (GnRH, hCG, LH and progesterone) on the regulation of corpus luteum (CL) and ovarian blood flow. Diestrous mares received a single treatment of saline, 100μg gonadorelin (GnRH), or 1500IU hCG 10days after ovulation. Plasma LH and progesterone concentrations, resistance index (RI) for ovarian artery blood-flow, and percentage of corpus luteum (CL) with color-Doppler signals of blood flow were determined immediately before treatment (hour 0) and at hours 0.25, 0.5, 1, 1.5, 2, 3, 4, 5, and 6. In the GnRH group, LH increased (P
ISSN:0378-4320
1873-2232
DOI:10.1016/j.anireprosci.2016.11.010